IL6 Antibody - #DF6087

>>奖励金 进行中>>
>>8折购 进行中>>
(392)   (142)  
产品: IL6 抗体
货号: DF6087
描述: Rabbit polyclonal antibody to IL6
应用: WB IHC IF/ICC
文献验证: WB, IHC, IF/ICC
反应: Human, Mouse, Rat
预测: Bovine
蛋白号: P05231
RRID: AB_2838055

浏览相似产品>>

   规格 价格 库存
 50ul RMB¥ 1000 1250 现货
 100ul RMB¥ 1840 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

联系销售
相关下载
MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
IL6 Antibody detects endogenous levels of total IL6.
RRID:
AB_2838055
引用格式: Affinity Biosciences Cat# DF6087, RRID:AB_2838055.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Interleukin BSF 2; B cell differentiation factor; B cell stimulatory factor 2; B-cell stimulatory factor 2; BSF 2; BSF-2; BSF2; CDF; CTL differentiation factor; Hepatocyte stimulatory factor; HGF; HSF; Hybridoma growth factor; Hybridoma growth factor Interferon beta-2; IFN-beta-2; IFNB2; IL 6; IL-6; IL6; IL6_HUMAN; Interferon beta 2; Interferon beta-2; Interleukin 6; Interleukin 6 (interferon beta 2); Interleukin BSF 2; Interleukin-6;

抗原和靶标

免疫原:

A synthesized peptide derived from human IL6, corresponding to a region within the internal amino acids.

基因/基因ID:
IL6(3569)
描述:
Interleukin-6 (IL-6) is a multifunctional cytokine with a wide variety of biological functions. IL-6 is implicated in the final differentiation of B-cells into immunoglobulin-secreting cells (1), myeloma and plasmacytoma growth (2), nerve cell differentiation, and activation of hepatocytes and mitogen-stimulated helper T cells (3). Upon activation, IL-6 induces at least three major signaling pathways: JAK/STAT, PI-3 kinase and MAPK (4,5).

研究领域

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > FoxO signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > TNF signaling pathway.   (View pathway)

· Human Diseases > Drug resistance: Antineoplastic > EGFR tyrosine kinase inhibitor resistance.

· Human Diseases > Drug resistance: Antineoplastic > Antifolate resistance.

· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.

· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).

· Human Diseases > Neurodegenerative diseases > Prion diseases.

· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.

· Human Diseases > Infectious diseases: Bacterial > Pertussis.

· Human Diseases > Infectious diseases: Bacterial > Legionellosis.

· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).

· Human Diseases > Infectious diseases: Parasitic > African trypanosomiasis.

· Human Diseases > Infectious diseases: Parasitic > Malaria.

· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Human Diseases > Infectious diseases: Viral > Hepatitis B.

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Infectious diseases: Viral > Influenza A.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).

· Human Diseases > Immune diseases > Rheumatoid arthritis.

· Human Diseases > Immune diseases > Graft-versus-host disease.

· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).

· Organismal Systems > Immune system > Toll-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Cytosolic DNA-sensing pathway.   (View pathway)

· Organismal Systems > Immune system > Hematopoietic cell lineage.   (View pathway)

· Organismal Systems > Immune system > IL-17 signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

· Organismal Systems > Immune system > Intestinal immune network for IgA production.   (View pathway)

文献引用

1). Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis. Signal transduction and targeted therapy, 2024 (PubMed: 39428541) [IF=40.8]
2). A bioinspired polymeric membrane-enclosed insulin crystal achieves long-term, self-regulated drug release for type 1 diabetes therapy. Nature nanotechnology, 2025 (PubMed: 40011600) [IF=38.1]
3). An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs. Nature nanotechnology, 2024 (PubMed: 39223256) [IF=38.1]

Application: IF/ICC    Species: Mouse    Sample:

Fig. 6 |. Materials retention and histological testing. a, Live-animal imaging (top) and ex vivo fluorescence imaging (bottom) of mice after oral administration of Cy5PPF-ins (50 μl; insulin-equiv. concentration, 1 mg ml−1). The major organs included heart, lung, liver, spleen and kidney (from up to down). The colour bar indicates the radiant efficiency from 1.40 × 108 to 8.66 × 108 p s−1 cm−2 sr−1 (top) and from 7.35 × 107 to 9.99 × 107 p s−1 cm−2 sr−1 (bottom). b, Representative images of TNF-α-, IL-6-, Ly6G- and TUNEL-stained intestine samples after treatment with PBS (top) or PPF-ins (1,000 U kg−1; bottom) for 2 h. Ten per cent of PPF was labelled with Cy5 (red). Scale bar, 100 μm. c, Representative images of TNF-α-, IL-6-, Ly6G- and TUNEL-stained liver samples after treatment with PBS or Cy5PPF-ins (100 U kg−1) for seven consecutive days. Scale bar, 100 μm. d–i, Haematology, biochemistry and lipids analysis in healthy mice treated with PPF-ins or PBS (n = 5 biologically independent samples, mean ± SD). Blood cell counts (d), biochemistry (e) and lipids analysis (f) of mice after treatment with PBS or PPF-ins (1,000 U kg−1) for 2 h. Blood cell counts (g), biochemistry (h) and lipids analysis (i) of mice after treatment with PBS or Cy5PPF-ins (100 U kg−1) for seven consecutive days. RBC, red blood cell; PLT, platelet; WBC, white blood cell; Neu, neutrophil; Lym, lymphocyte; Mon, monocyte; Eos, eosinophil; Bas, basophil; ALP, alkaline phosphatase; AST, aspartate transaminase; ALT, alanine transaminase; BUN, blood urea nitrogen; TC, total cholesterol; TG, triglycerides LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
4). Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment. Nature nanotechnology, 2024 (PubMed: 38898135) [IF=38.1]
5). Week-long normoglycaemia in diabetic mice and minipigs via a subcutaneous dose of a glucose-responsive insulin complex. Nature biomedical engineering, 2023 (PubMed: 38057427) [IF=28.1]
6). Flexible Photovoltaic Neurostimulator for Analgesia. Advanced materials (Deerfield Beach, Fla.), 2025 (PubMed: 40817613) [IF=27.4]
7). Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles. Advanced materials (Deerfield Beach, Fla.), 2025 (PubMed: 40066473) [IF=27.4]
8). Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response. Nature cancer, 2025 (PubMed: 40494938) [IF=22.7]
9). Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction. Nature Communications, 2022 (PubMed: 36418325) [IF=16.6]
10). A biodegradable, flexible photonic patch for in vivo phototherapy. Nature Communications, 2023 (PubMed: 37244895) [IF=16.6]
加载更多

限制条款

产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）

产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。

产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。

Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。

产品仅供科学研究使用。不用于诊断和治疗。 

产品未经授权不得转售。

Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.