SOCS1 Antibody - #AF5378

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产品: SOCS1 抗体
货号: AF5378
描述: Rabbit polyclonal antibody to SOCS1
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Rabbit, Dog
蛋白号: O15524
RRID: AB_2837863

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
SOCS1 Antibody detects endogenous levels of total SOCS1.
RRID:
AB_2837863
引用格式: Affinity Biosciences Cat# AF5378, RRID:AB_2837863.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CISH 1; CISH1; Cytokine inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; Janus kinase binding protein; SOCS 1; SOCS-1; Socs1; SOCS1_HUMAN; SSI 1; SSI-1; SSI1; STAT induced STAT inhibitor 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Supressor of cytokine signalling 1; TEC interacting protein 3; Tec-interacting protein 3; TIP 3; TIP-3; TIP3;

抗原和靶标

免疫原:

A synthesized peptide derived from human SOCS1, corresponding to a region within the internal amino acids.

基因/基因ID:
SOCS1(8651)
描述:
The SOCS (suppressor of cytokine signaling) gene family consists of a group of proteins that negatively regulate cytokine signal transduction. The SOCS family proteins contain a central SH2 domain and a carboxy-terminal region termed the “SOCS box.”

研究领域

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

· Genetic Information Processing > Folding, sorting and degradation > Ubiquitin mediated proteolysis.   (View pathway)

· Human Diseases > Endocrine and metabolic diseases > Type II diabetes mellitus.

· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

· Organismal Systems > Endocrine system > Insulin signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Prolactin signaling pathway.   (View pathway)

文献引用

1). Ferroptosis-associated molecular classification characterized by distinct tumor microenvironment profiles in colorectal cancer. International journal of biological sciences, 2022 (PubMed: 35342352) [IF=8.2]
2). Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils. Stem cell research & therapy, 2025 (PubMed: 39901221) [IF=7.5]
3). Methyltransferase METTL3 regulates neuropathic pain through m6A methylation modification of SOCS1. Neuropharmacology, 2024 (PubMed: 39357736) [IF=4.6]
4). HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCS/JAK2/STAT/PPAR-γ Signalling Pathway. MEDIATORS OF INFLAMMATION, 2019 (PubMed: 31772499) [IF=4.4]
5). Berberine induces SOCS1 pathway to reprogram the M1 polarization of macrophages via miR-155–5p in colitis-associated colorectal cancer. European Journal of Pharmacology, 2023 (PubMed: 37059377) [IF=4.2]
6). miR-196b-5p Affects Macrophage Polarization and Inflammation in Endometriosis. Iranian journal of immunology : IJI, 2024 (PubMed: 39243139) [IF=1.1]
7). ProS/Mer alleviates sepsis-induced neuromuscular dysfunction by inhibiting TLR4/MyD88/NF-κB signals. Research Square, 2022

Application: WB    Species: Rat    Sample:

Figure 6. Knockout of Mer reduced STAT1 activation and SOCS expression after CLP. Representative immunoblots and quantification showing the expression of TLR4 (A), NF-κB (B) was significantly increased in WT and Mer-/- group at day 4 after CLP; however, the expression of phosphorylated STAT1 (p-STAT1) (C), SOCS1 (D), and SOCS3 (E) were significantly decreased at day 4 after CLP. Data are expressed as fold change compared to the Sham + WT group; n = 5 rats per group. *P < 0.05 compared to Sham + WT group,

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