FOXO1A Antibody - #AF6418

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产品: FOXO1A 抗体
货号: AF6418
描述: Rabbit polyclonal antibody to FOXO1A
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Dog, Chicken, Xenopus
蛋白号: Q12778
RRID: AB_2835248

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
FOXO1A Antibody detects endogenous levels of total FOXO1A.
RRID:
AB_2835248
引用格式: Affinity Biosciences Cat# AF6418, RRID:AB_2835248.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

FKH 1; FKH1; FKHR; Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma); Forkhead box O1; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; Forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FoxO transcription factor; foxo1; FOXO1_HUMAN; FOXO1A; OTTHUMP00000018301;

抗原和靶标

免疫原:

A synthesized peptide derived from human FOXO1A, corresponding to a region within the internal amino acids.

基因/基因ID:
FOXO1(2308)
描述:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation.

研究领域

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > FoxO signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > AMPK signaling pathway.   (View pathway)

· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Cancers: Specific types > Prostate cancer.   (View pathway)

· Organismal Systems > Aging > Longevity regulating pathway.   (View pathway)

· Organismal Systems > Aging > Longevity regulating pathway - multiple species.   (View pathway)

· Organismal Systems > Endocrine system > Insulin signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Glucagon signaling pathway.

文献引用

1). Oleic and linoleic acids promote chondrocyte apoptosis by inhibiting autophagy via downregulation of SIRT1/FOXO1 signaling. Biochimica et biophysica acta. Molecular basis of disease, 2024 (PubMed: 38378085) [IF=4.2]

Application: WB    Species: Human    Sample:

Fig. 3. Identification of differentially expressed mRNAs and gene set enrichment analysis. (A) Heatmap of differentially expressed genes (DEGs) between chondrocytes treated with 20 μM OLA or LA and control samples (three different samples in each group) (B) Schematic illustration showing the overlap between the target DEGs from the OLA or LA treatment group and those from the control group. (C) Classification of the overlapping genes in accordance with the Gene Ontology (GO) categories of biological processed, cellular component, and molecular function. The vertical axis represents the number of DEGs corresponding to the number of GO terms assigned to a particular GO category. (D) GO chord diagram representing the results of cluster analysis of the DEGs in 10 categories. (E) Western blot analysis of FOXO1, SIRT1, ATG5, LC3-II, and BAX expression was conducted in chondrocytes treated with 20 μM OLA or LA. (F) Quantitative analysis of the protein levels in (E) (n = 3) (G) Real-time PCR analysis showing FOXO1 and SIRT1 expression in 20 μM OLA- and LA-induced normal chondrocytes (n = 3). Error bars present mean ± SD. * p < 0.05, ** p < 0.01, and *** p < 0.001.

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