Calmodulin1/2/3 Antibody - #AF6353

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产品: Calmodulin1/2/3 抗体
货号: AF6353
描述: Rabbit polyclonal antibody to Calmodulin1/2/3
应用: WB IHC IF/ICC
文献验证: IHC
反应: Human, Mouse, Rat
蛋白号: P0DP23 | P0DP24 | P0DP25
RRID: AB_2835158

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Calmodulin1/2/3 Antibody detects endogenous levels of total Calmodulin1/2/3.
RRID:
AB_2835158
引用格式: Affinity Biosciences Cat# AF6353, RRID:AB_2835158.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CALM 1;CALM 2;CALM 3;CALM;CALM1;CALM2;CALM3;CALML2;calmodulin 1 (phosphorylase kinase, delta);Calmodulin 1;Calmodulin 2 (phosphorylase kinase, delta);Calmodulin 2;Calmodulin 3 (phosphorylase kinase, delta);Calmodulin 3;CAM 2;CAM 3;CAM;CAM I;CAM1;CAM2;CAM3;CAMB;CAMC;CAMI;CAMII;CAMIII;CPVT4;DD132;FLJ99410 antibodyLP7057 protein;PHKD;PHKD2;PHKD3;phosphorylase kinase delta;phosphorylase kinase, delta subunit;

抗原和靶标

免疫原:

A synthesized peptide derived from human Calmodulin, corresponding to a region within the internal amino acids.

基因/基因ID:
CALM1(801) | CALM2(805) | CALM3(808)
描述:
Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium.

研究领域

· Cellular Processes > Cell growth and death > Oocyte meiosis.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Rap1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.

· Environmental Information Processing > Signal transduction > Apelin signaling pathway.   (View pathway)

· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.

· Human Diseases > Substance dependence > Amphetamine addiction.

· Human Diseases > Substance dependence > Alcoholism.

· Human Diseases > Infectious diseases: Bacterial > Pertussis.

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Glioma.   (View pathway)

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Circulatory system > Vascular smooth muscle contraction.   (View pathway)

· Organismal Systems > Environmental adaptation > Circadian entrainment.

· Organismal Systems > Nervous system > Long-term potentiation.

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

· Organismal Systems > Nervous system > Dopaminergic synapse.

· Organismal Systems > Sensory system > Olfactory transduction.

· Organismal Systems > Sensory system > Phototransduction.

· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels.   (View pathway)

· Organismal Systems > Endocrine system > Insulin signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Estrogen signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Melanogenesis.

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

· Organismal Systems > Endocrine system > Glucagon signaling pathway.

· Organismal Systems > Endocrine system > Renin secretion.

· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.

· Organismal Systems > Digestive system > Salivary secretion.

· Organismal Systems > Digestive system > Gastric acid secretion.

文献引用

1). Effect of PLC-β1/CaM signaling pathway mediated by AT1R on the occurrence and development of hepatocellular carcinoma. Cancer cell international, 2021 (PubMed: 34727945) [IF=5.8]

Application: IHC    Species: human    Sample:

Fig. 3 The expression levels of target proteins in serum and liver tissue of HCC patients. A, B ELISA was used to detect the levels of Ang II and AT1R-Ab in serum of HCC patients and normal people. There were 65 patients with HCC, 56 patients returned to the clinic 6 months after operation, and 82 normal people. *P  <  0.05, **P  <  0.01 VS normal population; #P  <  0.05 VS preoperative HCC patients (E-S grades I + II); and P  <  0.05 VS preoperative HCC patients (E-S grades III + IV). C, D Representative IHC images and semi-quantitative analysis showed the expressions of AT1R, PLC-β1 and CaM in different liver tissues (magnification,  × 200). *P  <  0.05, **P 
2). Voluntary wheel exercise improves glymphatic clearance and ameliorates colitis-associated cognitive impairment in aged mice by inhibiting TRPV4-induced astrocytic calcium activity. Experimental neurology, 2024 (PubMed: 38580155) [IF=4.6]
3). Identification and validation of a novel innate lymphoid cell-based signature to predict prognosis and immune response in liver cancer by integrated single-cell RNA analysis and bulk RNA sequencing. Translational cancer research, 2024 (PubMed: 39525025) [IF=1.5]

Application: IHC    Species: human    Sample:

Figure 12. The expression of the five key ILC genes verified by IHC. Representative 100× IHC images of (A) STK4, CALM1, (B) C2, RORA, and IL7R in different T stages of HCC. ILC, innate lymphoid cell; IHC, immunohistochemistry; HCC, hepatocellular carcinoma.

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