Phospho-NF kappaB p100/p52 (Ser866) Antibody - #AF3373

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产品: 磷酸化 NF kappaB p100/p52 (Ser866) 抗体
货号: AF3373
描述: Rabbit polyclonal antibody to Phospho-NF kappaB p100/p52 (Ser866)
应用: WB IHC IF/ICC IP
文献验证: IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: Q00653
RRID: AB_2834804

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WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IP, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-NF kappaB p100/p52 (Ser866) Antibody detects endogenous levels of NF kappaB p100/p52 only when phosphorylated at Serine 866.
RRID:
AB_2834804
引用格式: Affinity Biosciences Cat# AF3373, RRID:AB_2834804.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CVID10; DNA binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; LYT 10; NF kB2; NFKB p52/p100 subunit; Nuclear factor Kappa B subunit 2; Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p49/p100); Nuclear factor of kappa light polypeptide gene enhancer in B cells 2; Oncogene Lyt 10; p100; Transcription factor NFKB2;

抗原和靶标

免疫原:

A synthesized peptide derived from human NF- kappaB p100/p52 around the phosphorylation site of Ser866.

基因/基因ID:
NFKB2(4791)
描述:
NFkB-p100 a transcription factor of the nuclear factor-kappaB ( NFkB) group. Precursor of the p52 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions.

研究领域

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Legionellosis.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

· Human Diseases > Cancers: Specific types > Breast cancer.   (View pathway)

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

文献引用

1). An injectable self-lubricating supramolecular polymer hydrogel loaded with platelet lysate to boost osteoarthritis treatment. Journal of controlled release : official journal of the Controlled Release Society, 2024 (PubMed: 39362609) [IF=10.5]

Application: IHC    Species: Rat    Sample:

Fig. 8. Immunohistochemistry staining. (A) Representative immunohistochemical staining images of collagen II, MMP-13, P-P100, and NIK proteins. (B) Quantification of relative collagen II, MMP-13, P-P100 and NIK expression. (n = 6, ns: no significance, ****: P < 0.0001, ***: P < 0.001, **: P < 0.01, *: P < 0.05).
2). Fingolimod protects against cerebral ischemia reperfusion injury in rats by reducing inflammatory cytokines and inhibiting the activation of p38 MAPK and NF-κB signaling pathways. NEUROSCIENCE LETTERS, 2022 (PubMed: 34942319) [IF=2.5]

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