Phospho-TAK1 (Thr184/Thr187) Antibody - #AF4379

>>买2送1 进行中>>
>>赠JD卡 进行中>>
(4)   (3)  
产品: 磷酸化 TAK1 (Thr184/Thr187) 抗体
货号: AF4379
描述: Rabbit polyclonal antibody to Phospho-TAK1 (Thr184/Thr187)
应用: WB
文献验证: WB
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
蛋白号: O43318
RRID: AB_2844444

浏览相似产品>>

   规格 价格 库存
 50ul RMB¥ 1800 现货
 100ul RMB¥ 2800 现货
 200ul RMB¥ 3800 现货

货期: 当天发货

联系销售
相关下载
MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-TAK1 (Thr184/Thr187) Antibody detects endogenous levels of TAK1 only when phosphorylated at Thr184/187.
RRID:
AB_2844444
引用格式: Affinity Biosciences Cat# AF4379, RRID:AB_2844444.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

M3K7_HUMAN; MAP3K 7; Map3k7; MEKK7; Mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; TAK1; TGF beta activated kinase 1; TGF-beta-activated kinase 1; TGF1a; Transforming growth factor beta activated kinase 1; Transforming growth factor-beta-activated kinase 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human TAK1 around the phosphorylation site of Thr184/187.

基因/基因ID:
MAP3K7(6885)

研究领域

· Cellular Processes > Transport and catabolism > Autophagy - animal.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Adherens junction.   (View pathway)

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > AMPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Wnt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > TNF signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.

· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

· Organismal Systems > Immune system > Toll-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > IL-17 signaling pathway.   (View pathway)

· Organismal Systems > Immune system > T cell receptor signaling pathway.   (View pathway)

文献引用

1). Tripartite motif 38 attenuates cardiac fibrosis after myocardial infarction by suppressing TAK1 activation via TAB2/3 degradation. iScience, 2022 (PubMed: 35982795) [IF=5.8]

Application: WB    Species: Mouse    Sample: cardiac fibrosis

Figure 5 TRIM38 inactivates MAPK signaling during myocardial infarction (A and B) Representative Western blotting (Up) and quantitative results (Down) of total (T-) and phospho- (P-) TAK1-p38/ERK1/2/JNK1/2 levels in mice myocardium subjected to sham or MI operation. n = 4–6/each group; ∗p < 0.05, ∗∗p < 0.01. (C and D) Representative Western blotting (Up) and quantitative results (Down) results of total- (T-) and phospho- (P-) TAK1-p38/ERK1/2/JNK1/2 levels in NRCFs transfected with AdshTRIM38 or AdTRIM38 stimulated with angiotensin Ⅱ. Three independent experiments. ∗p < 0.05, ∗∗p < 0.01. GAPDH was used as a loading control. The result was means ± S.D., and statistical analyses were performed using one-way ANOVA.
2). Downregulation of RSAD2 ameliorates keratinocyte hyperproliferation and skin inflammation in psoriasis via the TAK1/NF-κB axis. Biochemical pharmacology, 2025 (PubMed: 39848474) [IF=5.3]
3). 5Z-7-Oxozaenol attenuates cuprizone-induced demyelination in mice through microglia polarization regulation. Brain and behavior, 2024 (PubMed: 38648385) [IF=2.6]
4). Transferrin-dependent crosstalk between the intestinal tract and commensal microbes contributes for immune tolerance. bioRxiv, 2020

Application: WB    Species: Human    Sample: THP-1 cells

Figure 4. Transferrin inhibits TLR4 activation. THP-1 cells were stimulated in presence or absence of transferrin by LPS for 8 h. Total and phosphorylated TAK1, IKKα, IκBα, and p65 of the myD88-dependent pathway and TBK1 and IRF3 of the myD88-independent pathway in THP-1 cells were analyzed by Western blotting, respectively. Corresponding quantifications are shown on right (six panels). β-actin was used as loading control. Data represent means ± SD of five independent experiments, *p < 0.05, **p < 0.01 by one-way ANOVA with Dunnett’s post-hoc test . Tf: transferrin.

限制条款

产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）

产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。

产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。

Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。

产品仅供科学研究使用。不用于诊断和治疗。 

产品未经授权不得转售。

Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.