Phospho-RIPK1 (Ser161) Antibody - #AF7377

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产品: 磷酸化 RIPK1 (Ser161) 抗体
货号: AF7377
描述: Rabbit polyclonal antibody to Phospho-RIPK1 (Ser161)
应用: WB IHC IF/ICC
文献验证: IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: Q13546
RRID: AB_2843817

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   规格 价格 库存
 100ul RMB¥ 2800 现货
 200ul RMB¥ 3800 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
Phospho-RIPK1 (Ser161) Antibody detects endogenous levels of RIPK1 only when phosphorylated at Ser161.
RRID:
AB_2843817
引用格式: Affinity Biosciences Cat# AF7377, RRID:AB_2843817.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Cell death protein RIP; FLJ39204; OTTHUMP00000039163; Receptor (TNFRSF) interacting serine threonine kinase 1; receptor interacting protein 1; Receptor interacting protein; Receptor interacting protein kinase 1; Receptor interacting serine threonine protein kinase 1; Receptor TNFRSF interacting serine threonine kinase 1; Receptor-interacting protein 1; Receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP 1; RIP; Rip-1; RIP1; RIPK 1; Ripk1; RIPK1_HUMAN; Serine threonine protein kinase RIP; Serine/threonine-protein kinase RIP;

抗原和靶标

免疫原:

A synthesized peptide derived from human RIP around the phosphorylation site of Ser161.

基因/基因ID:
RIPK1(8737)

研究领域

· Cellular Processes > Cell growth and death > Apoptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > TNF signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Viral > Hepatitis C.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Organismal Systems > Immune system > Toll-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Cytosolic DNA-sensing pathway.   (View pathway)

文献引用

1). Adenosine kinase inhibition prevents severe acute pancreatitis via suppressing inflammation and acinar cell necroptosis. Frontiers in Cell and Developmental Biology, 2022 (PubMed: 35281076) [IF=4.6]
2). Axl deficiency promotes the neuroinvasion of Japanese encephalitis virus by enhancing IL-1α production from pyroptotic macrophages. Journal of Virology, 2020 (PubMed: 32611752) [IF=4.0]

Application: IF/ICC    Species: mouse    Sample: peritoneal macrophages

Fig. 12. | Effect of Axl on the cell death mode of in situ peritoneal macrophages.Four-week-old Axl-/- and Axl+/- mice receive an i.p. injection of 10 4 PFU of JEV.Specifically, for PI3K inhibition in the in situ Axl+/-peritoneal macrophages, an i.p.injection of LY294002 (1.25 mg per mouse) is administered 1 h prior to i.p. infection.At 24 hpi, the in situ peritoneal macrophages are isolated.(D) IF staining of RIPK1(marker of necroptosis) in the in situ peritoneal macrophages.

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