Methyl-PGC1 alpha (Lys224) Antibody - #AF8600

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产品: Methyl-PGC1 alpha (Lys224) 抗体
货号: AF8600
描述: Rabbit polyclonal antibody to Methyl-PGC1 alpha (Lys224)
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Rabbit, Dog
蛋白号: Q9UBK2
RRID: AB_2843451

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   规格 价格 库存
 100ul RMB¥ 2500 现货
 200ul RMB¥ 3500 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Methyl-PGC1 alpha(K224) antibody detects endogenous levels of total Methyl-PGC1 alpha(K224).
RRID:
AB_2843451
引用格式: Affinity Biosciences Cat# AF8600, RRID:AB_2843451.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

L PGC 1alpha; LEM6; Ligand effect modulator 6; Peroxisome proliferative activated receptor gamma coactivator 1 alpha; Peroxisome proliferative activated receptor gamma coactivator 1; Peroxisome proliferator activated receptor gamma coactivator 1 alpha; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 3ext; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 8a; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B5; Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B5 NT; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC 1 (alpha); PGC 1 alpha; PGC 1v; PGC-1-alpha; PGC1; PGC1(alpha); PGC1A; PGC1v; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1; PPAR gamma coactivator variant form; PPAR-gamma coactivator 1-alpha; PPARGC 1 alpha; PPARGC-1-alpha; PPARGC1; PPARGC1A; PRGC1_HUMAN;

抗原和靶标

免疫原:

A synthesized peptide derived from human Methyl-PGC1 alpha(K224), corresponding to a region within the internal amino acids.

基因/基因ID:
PPARGC1A(10891)
描述:
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis.

研究领域

· Environmental Information Processing > Signal transduction > AMPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Apelin signaling pathway.   (View pathway)

· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Organismal Systems > Aging > Longevity regulating pathway.   (View pathway)

· Organismal Systems > Endocrine system > Insulin signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Adipocytokine signaling pathway.

· Organismal Systems > Endocrine system > Glucagon signaling pathway.

文献引用

1). Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025 (PubMed: 39630931) [IF=15.1]
2). Patchouli alcohol alleviates metabolic dysfunction-associated steatohepatitis via inhibiting mitochondria-associated endoplasmic reticulum membrane disruption-induced hepatic steatosis and inflammation in rats. International immunopharmacology, 2024 (PubMed: 38971107) [IF=4.8]
3). The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria. CHEMICO-BIOLOGICAL INTERACTIONS, 2021 (PubMed: 33676887) [IF=4.7]

Application: WB    Species: Rat    Sample: left atrial tissue

Fig. 9. Effects of AD2 on p-AMPK, PGC-1 α , and PPARγ expression in isolated beating rat left atria. Ang II, angiotensin II (5.0 μ mol/L); AICAR, 5-aminoimidazole-4- carboxamide-1-β- D -ribofuranoside, (500.0 μ mol/L); Cont, control; Dor, dorsomorphin, (10.0 μ mol/L); AD2, 25-hydroxy protopanaxadiol (5.0 μ mol/L); SB239063 (10.0 μ mol/L); Pim (4.0 μ mol/L). Data are presented as mean ± SEM, *P < 0.05 vs. Cont; # P < 0.05 vs. Ang II; & P < 0.05 vs. AD2; % P < 0.05 vs. AD2 + Ang II; + P < 0.05 vs. Dor.

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