产品: CKS2 抗体
货号: AF0616
描述: Rabbit polyclonal antibody to CKS2
应用: WB IHC IF/ICC
反应: Human, Mouse
预测: Pig, Zebrafish, Bovine, Sheep, Dog, Chicken, Xenopus
分子量: 9kDa; 10kD(Calculated).
蛋白号: P33552
RRID: AB_2834233

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Zebrafish(91%), Bovine(100%), Sheep(100%), Dog(100%), Chicken(92%), Xenopus(100%)
克隆:
Polyclonal
特异性:
CKS2 Antibody detects endogenous levels of total CKS2.
RRID:
AB_2834233
引用格式: Affinity Biosciences Cat# AF0616, RRID:AB_2834233.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CDC28; CDC28 protein kinase 2; CDC28 protein kinase regulatory subunit 2; CKS 2; CKS-2; CKS1(S. cerevisiae Cdc28/Cdc2 kinase subunit) homolog 2; Cks2; CKS2_HUMAN; CKSHS2; Cyclin dependent kinases regulatory subunit 2; Cyclin-dependent kinases regulatory subunit 2;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
描述:
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein.
序列:
MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLPKDQQK

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
92
Zebrafish
91
Horse
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P33552 作为底物

Site PTM Type Enzyme
K4 Acetylation
K4 Ubiquitination
Y7 Phosphorylation
Y8 Phosphorylation
K11 Ubiquitination
Y12 Phosphorylation
Y17 Phosphorylation
K30 Ubiquitination
K34 Ubiquitination
S39 Phosphorylation
S51 Phosphorylation

研究背景

功能:

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

亚基结构:

Forms a homohexamer that can probably bind six kinase subunits.

蛋白家族:

Belongs to the CKS family.

研究领域

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Small cell lung cancer.   (View pathway)

文献引用

1). Fan Feng et al. Cyclin-dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial-mesenchymal transition-like process in glioma by activating TGFβ/SMAD signaling. Cancer Medicine 2022 Oct 25. (PubMed: 36284444) [IF=4.0]

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