ES8L2 Antibody - #AF0463

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产品: ES8L2 抗体
货号: AF0463
描述: Rabbit polyclonal antibody to ES8L2
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Horse, Dog, Chicken, Xenopus
分子量: 81kDa; 81kD(Calculated).
蛋白号: Q9H6S3
RRID: AB_2834218

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Zebrafish(100%), Bovine(100%), Horse(100%), Dog(100%), Chicken(91%), Xenopus(100%)
克隆:
Polyclonal
特异性:
ES8L2 Antibody detects endogenous levels of total ES8L2.
RRID:
AB_2834218
引用格式: Affinity Biosciences Cat# AF0463, RRID:AB_2834218.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Epidermal growth factor receptor kinase substrate 8 like protein 2; Epidermal growth factor receptor kinase substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8 like protein 2; Epidermal growth factor receptor pathway substrate 8 related protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8 like 2; EPS8 like protein 2; EPS8 related protein 2; EPS8-like protein 2; EPS8-related protein 2; EPS8L 2; EPS8L2; EPS8R 2; EPS8R2; ES8L2_HUMAN; FLJ16738; FLJ21935; FLJ22171; MGC126530; MGC3088;

抗原和靶标

免疫原:
Uniprot:

Q9H6S3(ES8L2_HUMAN) >>Visit HPA database.

基因/基因ID:
EPS8L2(64787)
表达:
Q9H6S3 ES8L2_HUMAN:

Detected in fibroblasts and placenta.

描述:
EPS8L2 Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Belongs to the EPS8 family. Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin. 2 isoforms of the human protein are produced by alternative splicing.
序列:
MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRGEDS

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Dog
100
Xenopus
100
Zebrafish
100
Chicken
91
Pig
0
Sheep
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9H6S3 作为底物

Site PTM Type Enzyme
S2 Phosphorylation
S4 Phosphorylation
S8 Phosphorylation
S17 Phosphorylation
S21 Phosphorylation
S28 Phosphorylation
K30 Ubiquitination
S40 Phosphorylation
K77 Ubiquitination
K84 Ubiquitination
S100 Phosphorylation
S108 Phosphorylation
T125 Phosphorylation
T184 Phosphorylation
S197 Phosphorylation
S217 Phosphorylation
S231 Phosphorylation
S240 Phosphorylation
K251 Ubiquitination
K275 Ubiquitination
T303 Phosphorylation
S368 Phosphorylation
S449 Phosphorylation
S455 Phosphorylation
S459 Phosphorylation
S463 Phosphorylation
T465 Phosphorylation
S466 Phosphorylation
T469 Phosphorylation
S479 Phosphorylation
S480 Phosphorylation
T483 Phosphorylation
T490 Phosphorylation
Y501 Phosphorylation
S512 Phosphorylation
Y540 Phosphorylation
S570 Phosphorylation
T572 Phosphorylation
S628 Phosphorylation
K663 Acetylation
Y678 Phosphorylation
K690 Ubiquitination
S693 Phosphorylation
S695 Phosphorylation
K703 Ubiquitination

研究背景

功能:

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).

细胞定位:

Cytoplasm. Cell projection>Stereocilium.
Note: Localizes at the tips of the stereocilia of the inner and outer hair cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Detected in fibroblasts and placenta.

亚基结构:

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.

蛋白家族:

Belongs to the EPS8 family.

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