AZI2 Antibody - #AF0553

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产品: AZI2 抗体
货号: AF0553
描述: Rabbit polyclonal antibody to AZI2
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 48kDa; 45kD(Calculated).
蛋白号: Q9H6S1
RRID: AB_2834217

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实验方案
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(82%), Bovine(82%), Horse(82%), Sheep(82%), Rabbit(82%), Dog(82%)
克隆:
Polyclonal
特异性:
AZI2 Antibody detects endogenous levels of total AZI2.
RRID:
AB_2834217
引用格式: Affinity Biosciences Cat# AF0553, RRID:AB_2834217.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

5 azacytidine induced protein 2; 5-azacytidine-induced protein 2; AA410145; AZ2; AZI2; AZI2_HUMAN; MGC112644; Nak associated protein 1; Nak-associated protein 1; NAP1; NF kappa B activating kinase associated protein 1; NF-kappa-B-activating kinase-associated protein 1; TILP; TILP(S);

抗原和靶标

免疫原:
Uniprot:

Q9H6S1(AZI2_HUMAN) >>Visit HPA database.

基因/基因ID:
AZI2(64343)
表达:
Q9H6S1 AZI2_HUMAN:

Widely expressed. Abundant expression seen in the pancreas and testis.

描述:
AZI2 Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1. Interacts with IKBKE, TBK1 and TICAM1. 2 isoforms of the human protein are produced by alternative splicing.
序列:
MDALVEDDICILNHEKAHKRDTVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENSLLKKRIRFLEEKLIARFEEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKKACAPVGCSEDLGRDSTKLHLMNFTATYTRHPPLLPNGKALCHTTSSPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWVFPSPPKSSETAFGETKTKTLPLPNLPPLHYLDQHNQNCLYKN

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
82
Horse
82
Bovine
82
Sheep
82
Dog
82
Rabbit
82
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9H6S1 作为底物

Site PTM Type Enzyme
S83 Phosphorylation
K91 Ubiquitination
S118 Phosphorylation
S120 Phosphorylation
K122 Ubiquitination
K131 Ubiquitination
T140 Phosphorylation
T144 Phosphorylation
S155 Phosphorylation
S156 Phosphorylation
K162 Ubiquitination
S164 Phosphorylation
K192 Ubiquitination
K194 Ubiquitination
K205 Ubiquitination
S213 Phosphorylation
T249 Phosphorylation
S250 Phosphorylation
T251 Phosphorylation
K255 Ubiquitination
S263 Phosphorylation
S270 Phosphorylation
K293 Ubiquitination
S300 Phosphorylation
S301 Phosphorylation
K313 Ubiquitination
S318 Phosphorylation
S325 Phosphorylation
S338 Phosphorylation
S343 Phosphorylation
S348 Phosphorylation
S353 Phosphorylation
K356 Ubiquitination
S357 Phosphorylation

研究背景

功能:

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed. Abundant expression seen in the pancreas and testis.

亚基结构:

Homodimer (By similarity). Interacts with IKBKE. Interacts with TBK1. Interacts with TICAM1.

(Microbial infection) Interacts with vaccinia virus protein C6.

研究领域

· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway.   (View pathway)

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