CBX6 Antibody - #AF0411
| 产品: | CBX6 抗体 |
| 货号: | AF0411 |
| 描述: | Rabbit polyclonal antibody to CBX6 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Xenopus |
| 分子量: | 44kDa; 44kD(Calculated). |
| 蛋白号: | O95503 |
| RRID: | AB_2834202 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0411, RRID:AB_2834202.
展开/折叠
Cbx 6; Cbx6; CBX6_HUMAN; Chromobox homolog 6; Chromobox protein homolog 6;
抗原和靶标
- O95503 CBX6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKFGAFALYKPPPAPLVAPSPGKAEASAPGPGLLLAAPAAPYDARSSGSSGCPSPTPQSSDPDDTPPKLLPETVSPSAPSWREPEVLDLSLPPESAATSKRAPPEVTAAAGPAPPTAPEPAGASSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCNPEDFEKVAAGVAGAAGGGGSIGASK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95503 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K18 | Ubiquitination | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| Y39 | Phosphorylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K100 | Acetylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| S107 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| T156 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K236 | Ubiquitination | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| T282 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot |
研究背景
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin. Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).
Nucleus. Chromosome.
Note: Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity).
Component of a PRC1-like complex. Distinct PRC1-like core complexes are composed of a RING1 subunit (RING1B or RING1A), one of the six PCGF proteins (PCGF1-6), one PHC protein (PHC1-3) and one of the CBX proteins (CBX2, CBX4, CBX6, CBX7 or CBX8). Interacts with PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6, RING1 and RNF2. May interact with HIST2H3A and HIST1H3A. Interacts (via chromodomain) with single-stranded RNA (ssRNA) (By similarity).
限制条款
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