ZNF265 Antibody - #AF0753

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产品: ZNF265 抗体
货号: AF0753
描述: Rabbit polyclonal antibody to ZNF265
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 34kDa; 37kD(Calculated).
蛋白号: O95218
RRID: AB_2834194

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
克隆:
Polyclonal
特异性:
ZNF265 Antibody detects endogenous levels of total ZNF265.
RRID:
AB_2834194
引用格式: Affinity Biosciences Cat# AF0753, RRID:AB_2834194.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ZRANB 2; DKFZp686J1831; DKFZp686N09117; FLJ41119; OTTHUMP00000011240; OTTHUMP00000011241; Zinc finger protein 265; Zinc finger RAN binding domain containing 2; Zinc finger Ran binding domain containing protein 2; Zinc finger splicing; ZIS; ZIS1; ZIS2; ZNF265;

抗原和靶标

免疫原:
Uniprot:

O95218(ZRAB2_HUMAN) >>Visit HPA database.

基因/基因ID:
ZRANB2(9406)
描述:
ZNF265 Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'- splice site selection. Belongs to the ZRANB2 family. Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
序列:
MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSSHSGSRSSSKKK

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - O95218 作为底物

Site PTM Type Enzyme
S9 Phosphorylation
T50 Phosphorylation
K54 Acetylation
K54 Ubiquitination
K59 Acetylation
K59 Ubiquitination
R61 Methylation
S65 Phosphorylation
S83 Phosphorylation
T90 Phosphorylation
K92 Acetylation
Y93 Phosphorylation
K95 Sumoylation
K95 Ubiquitination
Y102 Phosphorylation
Y114 Phosphorylation
S120 Phosphorylation
Y124 Phosphorylation
K137 Methylation
S143 Phosphorylation
S153 Phosphorylation
S165 Phosphorylation
K168 Ubiquitination
S181 Phosphorylation
K182 Ubiquitination
Y183 Phosphorylation
S188 Phosphorylation
S193 Phosphorylation
S206 Phosphorylation
S208 Phosphorylation
S213 Phosphorylation
S217 Phosphorylation
S218 Phosphorylation
S221 Phosphorylation
S249 Phosphorylation
S273 Phosphorylation
S275 Phosphorylation
S279 Phosphorylation
S280 Phosphorylation
S288 Phosphorylation
S290 Phosphorylation
T303 Phosphorylation
S305 Phosphorylation
S307 Phosphorylation
S318 Phosphorylation
S323 Phosphorylation
S326 Phosphorylation

翻译修饰 - O95218 作为激酶

Substrate Site Source
O95218-2 (ZRANB2) S188 Uniprot

研究背景

功能:

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

翻译修饰:

Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.

蛋白家族:

The RanBP2-type zinc fingers mediate binding to RNA.

Belongs to the ZRANB2 family.

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