CDKA2 Antibody - #AF0350

(2)  
产品: CDKA2 抗体
货号: AF0350
描述: Rabbit polyclonal antibody to CDKA2
应用: WB IHC
反应: Human, Mouse
分子量: 13kDa; 13kD(Calculated).
蛋白号: O75956
RRID: AB_2834190

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
CDKA2 Antibody detects endogenous levels of total CDKA2.
RRID:
AB_2834190
引用格式: Affinity Biosciences Cat# AF0350, RRID:AB_2834190.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CDK2 associated protein 2; CDK2-associated protein 2; CDK2AP2; CDKA2_HUMAN; Cyclin dependent kinase 2 associated protein 2; Cyclin-dependent kinase 2-associated protein 2; DOC 1 related protein; DOC-1-related protein; DOC-1R; DOC1R; FLJ10636; p14; tumor suppressor deleted in oral cancer related 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human CDKA2, corresponding to a region within C-terminal amino acids.

Uniprot:

O75956(CDKA2_HUMAN) >>Visit HPA database.

基因/基因ID:
CDK2AP2(10263)
表达:
O75956 CDKA2_HUMAN:

Ubiquitous.

描述:
CDK2AP2 Belongs to the CDK2AP family. Note: This description may include information from UniProtKB.
序列:
MSYKPIAPAPSSTPGSSTPGPGTPVPTGSVPSPSGSVPGAGAPFRPLFNDFGPPSMGYVQAMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART

翻译修饰 - O75956 作为底物

Site PTM Type Enzyme
K96 Ubiquitination
S97 Phosphorylation

研究背景

功能:

Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A.

翻译修饰:

Phosphorylated by MAPK1 and CDK2.

细胞定位:

Cytoplasm. Nucleus.
Note: Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous.

亚基结构:

Interacts with CDK2AP1. Interacts with CDK2. Interacts with MAPK1 (By similarity).

蛋白家族:

Belongs to the CDK2AP family.

限制条款

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