TACC1 Antibody - #AF0456

(2)  
产品: TACC1 抗体
货号: AF0456
描述: Rabbit polyclonal antibody to TACC1
应用: WB IF/ICC
反应: Human, Mouse
预测: Bovine, Horse, Sheep, Rabbit, Dog
分子量: 87kDa; 88kD(Calculated).
蛋白号: O75410
RRID: AB_2834182

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
TACC1 Antibody detects endogenous levels of total TACC1.
RRID:
AB_2834182
引用格式: Affinity Biosciences Cat# AF0456, RRID:AB_2834182.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

DKFZp686K18126; Ga 55; Ga55; Gastric cancer antigen Ga 55; Gastric cancer antigen Ga55; KIAA1103; TACC 1; Tacc1; TACC1_HUMAN; Taxin 1; Taxin-1; Taxin1; Transforming acidic coiled coil containing protein 1; Transforming acidic coiled-coil-containing protein 1;

抗原和靶标

免疫原:
Uniprot:

O75410(TACC1_HUMAN) >>Visit HPA database.

基因/基因ID:
TACC1(6867)
表达:
O75410 TACC1_HUMAN:

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.

描述:
Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4.Interacts with the Aurora kinases A and B (STK6 and AURKB).Interacts with LSM7, TDRD7 and SNRPG.Interacts with GCN5L2 and PCAF. 8 isoforms of the human protein are produced by alternative splicing. Protein Type: Unknown function
序列:
MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDSQAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Pig
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - O75410 作为底物

Site PTM Type Enzyme
A2 Acetylation
S4 Phosphorylation
S10 Phosphorylation
S44 Phosphorylation
T48 Phosphorylation
S50 Phosphorylation
S52 Phosphorylation
S54 Phosphorylation
S55 Phosphorylation
S57 Phosphorylation
T63 Phosphorylation
T68 Phosphorylation
K75 Methylation
K75 Ubiquitination
S94 Phosphorylation
S131 Phosphorylation
S147 Phosphorylation
S153 Phosphorylation
T168 Phosphorylation
K169 Ubiquitination
S179 Phosphorylation
S218 Phosphorylation
S225 Phosphorylation
S228 Phosphorylation Q9UQB9 (AURKC)
K234 Acetylation
K240 Acetylation
S248 Phosphorylation
T257 Phosphorylation
Y264 Phosphorylation
S267 Phosphorylation
T275 Phosphorylation
S276 Phosphorylation
K286 Ubiquitination
S287 Phosphorylation
S305 Phosphorylation
S347 Phosphorylation
T350 Phosphorylation
K360 Ubiquitination
S361 Phosphorylation
S454 Phosphorylation
K468 Ubiquitination
K471 Ubiquitination
T504 Phosphorylation
K517 Ubiquitination
Y533 Phosphorylation
S591 Phosphorylation
T616 Phosphorylation
K617 Ubiquitination
K640 Acetylation
K640 Ubiquitination
K647 Acetylation
K647 Ubiquitination
K665 Ubiquitination
S666 Phosphorylation
S687 Phosphorylation
K714 Ubiquitination
Y730 Phosphorylation
K734 Ubiquitination
K754 Acetylation
K756 Ubiquitination
S759 Phosphorylation
K783 Ubiquitination
K792 Ubiquitination
K800 Ubiquitination

研究背景

功能:

Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

翻译修饰:

Isoform 1 is heavily phosphorylated; isoform 6 is not.

细胞定位:

Cytoplasm. Nucleus. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Midbody.
Note: Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.

Membrane>Lipid-anchor.

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.

亚基结构:

Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF. Interacts with the thyroid hormone receptors THRB and THRA, predominantly with isoform alpha-2. The interaction with THRA isoform alpha-1 and THRB is decreased in the presence of thyroid hormone T3. Also interacts with other nuclear receptors, including ESR1, NR3C1, PPARG, RARA and RXRA, preferentially in the absence of their hormonal ligands.

蛋白家族:

Belongs to the TACC family.

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