MCSF Receptor Antibody - #AF0080

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产品: MCSF Receptor 抗体
货号: AF0080
描述: Rabbit polyclonal antibody to MCSF Receptor
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: P07333
RRID: AB_2833269

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
MCSF Receptor Antibody detects endogenous levels of total MCSF Receptor.
RRID:
AB_2833269
引用格式: Affinity Biosciences Cat# AF0080, RRID:AB_2833269.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

C FMS; CD 115; CD115; CD115 antigen; CFMS; Colony stimulating factor 1 receptor; Colony stimulating factor I receptor; CSF 1 R; CSF 1R; CSF-1 receptor; CSF-1-R; CSF1 R; CSF1R; CSF1R_HUMAN; CSFR; EC 2.7.10.1; FIM 2; FIM2; FMS; FMS proto oncogene; FMS protooncogene; HDLS; M-CSF Receptor; M-CSF-R; Macrophage colony stimulating factor 1 receptor; Macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v fms) oncogene homolog; MCSFR; Oncogen FMS; Proto-oncogene c-Fms; V-FMS McDonough feline sarcoma viral oncogen homolog, formerly;

抗原和靶标

免疫原:

A synthesized peptide derived from human MCSF Receptor, corresponding to a region within the internal amino acids.

基因/基因ID:
CSF1R(1436)
描述:
M-CSF Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF- 1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Homodimer or heterodimer; disulfide-linked. 3 isoforms of the human protein are produced by alternative splicing.

研究领域

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Rap1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Cancers: Specific types > Acute myeloid leukemia.   (View pathway)

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

· Organismal Systems > Immune system > Hematopoietic cell lineage.   (View pathway)

文献引用

1). Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy. JOURNAL OF CONTROLLED RELEASE, 2023 (PubMed: 36470332) [IF=10.5]
2). Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer. Journal of medicinal chemistry, 2023 (PubMed: 37220310) [IF=6.8]
3). JDF promotes the apoptosis of M2 macrophages and reduces epithelial-mesenchymal transition and migration of liver cancer cells by inhibiting CSF-1/PI3K/AKT signaling pathway. Heliyon, 2024 (PubMed: 39170340) [IF=4.0]

Application: WB    Species: Rat    Sample: liver cancer

Fig. 4 Treatment with JDF (3 mg/mL) and knocking down of shCSF-1 decreased the level of expression of CSF-1/CSF-1R in M2 macrophages. The shCSF-1 lentivirus was transfected. A. qPCR was used to determine the transcription level of CSF-1. B. Western blotting was used to determine the level of CSF-1 protein. C. The M2 macrophage marker CD206 was detected by flow cytometry. D. The extracellular CSF-1 concentration was determined by ELISA. E. Western blotting was used to determine the expression of CSF-1 and CSF-1R proteins after treatment with JDF. The original blots for the protein immunoblotting were provided in Supplementary Fig. S4. **P < 0.01 vs. Scramble, ##P < 0.01 vs. shCSF-1.
4). Effects of a calcium/vitamin D/Zinc combination on anti-osteoporosis in ovariectomized rats. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2023 (PubMed: 36773556) [IF=3.6]

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