FAP1 Antibody - #AF0739

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产品: FAP1 抗体
货号: AF0739
描述: Rabbit polyclonal antibody to FAP1
应用: WB IHC IF/ICC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: Q12884
RRID: AB_2834134

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
FAP1 Antibody detects endogenous levels of total FAP1.
RRID:
AB_2834134
引用格式: Affinity Biosciences Cat# AF0739, RRID:AB_2834134.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

170 kDa melanoma membrane bound gelatinase; 170 kDa melanoma membrane-bound gelatinase; DPPIV; FAP; FAPA; Integral membrane serine protease; SEPR_HUMAN; Seprase;Prolyl endopeptidase FAP; Dipeptidyl peptidase FAP; Fibroblast activation protein alpha; FAPalpha; FAP alpha; Gelatine degradation protease FAP; Post-proline cleaving enzyme; Serine integral membrane protease; SIMP; Surface-expressed protease; Seprase;

抗原和靶标

免疫原:

A synthesized peptide derived from human FAP1, corresponding to a region within the internal amino acids.

基因/基因ID:
FAP(2191)

文献引用

1). Development of ibuprofen-modified fibroblast activation protein radioligands to improve cancer therapy. European journal of medicinal chemistry, 2025 (PubMed: 39626520) [IF=6.0]
2). Synthesis and preclinical evaluation of novel 18F-labeled fibroblast activation protein tracers for positron emission tomography imaging of cancer-associated fibroblasts. European journal of medicinal chemistry, 2024 (PubMed: 38039792) [IF=6.0]
3). Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis. International immunopharmacology, 2024 (PubMed: 39471692) [IF=5.6]
4). Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3. Cancer Gene Therapy, 2023 (PubMed: 36890211) [IF=4.8]
5). β-elemene alleviates esophageal fibrosis after endoscopic submucosal dissection via the FAP-mediated PTEN-PI3K/AKT signaling pathway. Heliyon, 2024 (PubMed: 38807882) [IF=4.0]

Application: WB    Species: Human    Sample: PHEGFs

Fig. 3 β-elemene suppressed the proliferation and promoted the apoptosis of PHEGFs. (A) Endoscopic view after ESD and PHEGFs culture at different stages. (B) The primary cells were identified as fibroblasts by immunocytochemistry. (C) Flow cytometry detection of PHEGFs apoptosis rate after β-elemene intervention (n = 3). (D) CCK-8 to assess the proliferation of PHEGFs after β-elemene intervention (n = 3). (E) Flod change of FAP, p-PTEN, p-PI3K, and p-AKT (n = 3).*P < 0.05 versus the control group.
6). Antitumor Effect and Immune Response of Nanosecond Pulsed Electric Fields in Pancreatic Cancer. Frontiers in Oncology, 2021 (PubMed: 33634030) [IF=3.5]

Application: IHC    Species: Human    Sample: Pancreatic Cancer

Figure 8 IHC staining of viable tumor region at 3 and 7 days after the initiation of treatment. Representative micrographs of staining for α-SMA, FAP-α, HABP1. Five visual fields were randomly captured for each group. Magnification, 200×.
7). Effect of HepG2-Derived Exosome with PDGF-D Knockdown on Transformation of Normal Fibroblasts into Tumor-Associated Fibroblasts in Liver Cancer. Frontiers in bioscience (Landmark edition), 2025 (PubMed: 40152369) [IF=3.3]
8). Assessment of pulmonary fibrosis induced by paraquat using Al18F-NODA-FAPI-04 PET/CT. Internal and emergency medicine, 2023 (PubMed: 37284931) [IF=3.2]

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