MSN Antibody - #BF0619

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产品: MSN 抗体
货号: BF0619
描述: Mouse monoclonal antibody to MSN
应用: WB IHC ELISA FACS
文献验证: WB
反应: Human, Mouse, Monkey
蛋白号: P26038 | P35241 | P15311
RRID: AB_2833996

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   规格 价格 库存
 50ul RMB¥ 1800 现货
 100ul RMB¥ 2800 现货

货期: 当天发货

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产品描述

来源:
Mouse
应用:
ELISA 1:10000, WB 1:500-1:2000, IHC 1:200-1:1000, FCM 1:200-1:400
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Monkey
克隆:
Monoclonal [AFB1973]
特异性:
MSN antibody detects endogenous levels of total MSN.
RRID:
AB_2833996
引用格式: Affinity Biosciences Cat# BF0619, RRID:AB_2833996.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Epididymis luminal protein 70; HEL70; Membrane organizing extension spike protein; Membrane-organizing extension spike protein; MOES_HUMAN; Moesin; Moesin/anaplastic lymphoma kinase fusion protein; Msn; MSN/ALK fusion; CB567; CG12537; DFNB24; ESP10; Hh-induced MATH and BTB domain-containing protein; HIB; Moesin-B; Protein roadkill; RADI_HUMAN; Radixin; RDX; Villin 2 ezrin; CVIL; CVL; Cytovillin 2; Cytovillin; DKFZp762H157; Epididymis secretory protein Li 105; EZR; EZRI_HUMAN; Ezrin; FLJ26216; HEL S 105; MGC1584; p81; VIL 2; VIL2; Villin 2 (ezrin); Villin 2; Villin-2; Villin2;

抗原和靶标

免疫原:

Purified recombinant fragment of human MSN expressed in E. Coli.

基因/基因ID:
MSN(4478) | EZR(7430) | RDX(5962)
描述:
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.

研究领域

· Cellular Processes > Cellular community - eukaryotes > Tight junction.   (View pathway)

· Cellular Processes > Cell motility > Regulation of actin cytoskeleton.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Pathogenic Escherichia coli infection.

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

· Organismal Systems > Immune system > Leukocyte transendothelial migration.   (View pathway)

· Organismal Systems > Digestive system > Gastric acid secretion.

文献引用

1). Ectopic overexpression of GRK5 promotes malignant glioma progression closely associated with MSN-CD44 expression and glioma localization. Research Square, 2022

Application: WB    Species: Human    Sample: glioma

Figure 1. The expression and localization of GRK5 and MSN in glioma samples. A&B The mRNA levels of GRK5 and MSN in 42 glioma samples and their adjacent tissues were detected by qRT-PCR. C GRK5and MSN protein expressions in 12 glioma samples (4Ⅱ, 4Ⅲ, 4Ⅳ) were detected by Western blot. D GRK5 and MSN co-localization in glioma specimens. DAPI (4,6-diamidino-2-phenylindole) indicated nuclear (blue). GRK5 (green) mainly expressed in the cytoplasm of glioma cells, while MSN (red) showed faint cytoplasmic and strong membranous expression in glioma cells. The co-localization was shown in yellow (merge, arrows). E MSN/CD44 co-expression were observed in GBMs. DAPI indicated nuclear (blue). Both of MSN (green) and CD44 (red) showed faint cytoplasmic and moderate to strong membranous expression in glioma cells. The co-localization was shown in yellow (merge, arrows). Statistical analyses of relative mRNA expressions of GRK5 and MSN by Student’s t test.

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