ITGB1 Antibody - #BF0336

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产品: ITGB1 抗体
货号: BF0336
描述: Mouse monoclonal antibody to ITGB1
应用: WB IHC ELISA FACS
文献验证: WB, IHC
反应: Human, Mouse
蛋白号: P05556
RRID: AB_2833991

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   规格 价格 库存
 50ul RMB¥ 1800 现货
 100ul RMB¥ 2800 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Mouse
应用:
ELISA 1:10000, WB 1:500-1:2000, IHC 1:200-1:1000, FCM 1:200-1:400
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Monoclonal [AFB1968]
特异性:
ITGB1 antibody detects endogenous levels of total ITGB1.
RRID:
AB_2833991
引用格式: Affinity Biosciences Cat# BF0336, RRID:AB_2833991.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

beta1 integrin; CD29; Fibronectin receptor subunit beta; FNRB; Glycoprotein IIa; GP IIa; GPIIA; Integrin beta-1; Integrin subunit beta 1; integrin VLA-4 beta subunit; Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITB1_HUMAN; ITGB1; MDF2; MSK12; OTTHUMP00000019420; Very late activation protein, beta polypeptide; VLA BETA; VLA-4 subunit beta; VLA-BETA; VLAB; VLAbeta;

抗原和靶标

免疫原:

Purified recombinant fragment of human ITGB1 expressed in E. Coli.

基因/基因ID:
ITGB1(3688)
描述:
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.

研究领域

· Cellular Processes > Transport and catabolism > Phagosome.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Tight junction.   (View pathway)

· Cellular Processes > Cell motility > Regulation of actin cytoskeleton.   (View pathway)

· Environmental Information Processing > Signal transduction > Rap1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > ECM-receptor interaction.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs).   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.

· Human Diseases > Infectious diseases: Bacterial > Pathogenic Escherichia coli infection.

· Human Diseases > Infectious diseases: Bacterial > Shigellosis.

· Human Diseases > Infectious diseases: Bacterial > Pertussis.

· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.

· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

· Human Diseases > Cancers: Specific types > Small cell lung cancer.   (View pathway)

· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).

· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).

· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).

· Organismal Systems > Development > Axon guidance.   (View pathway)

· Organismal Systems > Immune system > Platelet activation.   (View pathway)

· Organismal Systems > Immune system > Leukocyte transendothelial migration.   (View pathway)

文献引用

1). CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway. Acta biochimica et biophysica Sinica, 2024 (PubMed: 38602002) [IF=3.3]
2). TGF-β1 promoted the infection of bovine mammary epithelial cells by Staphylococcus aureus through increasing expression of cells' fibronectin and integrin β1. Veterinary Microbiology, 2019 (PubMed: 31585649) [IF=2.4]

Application: WB    Species: mouse    Sample: BMECs

Fig. 3.| BMEC surface receptors were assessed using RT-PCR and western blot analyses. A. The genes associated with TGF-β1-mediated upregulation during S. aureus infection. B. The Fn and ITGB1 protein levels were significantly increased with TGF-β1 treatment. *, P < 0.05; **, P < 0.01.

Application: IF/ICC    Species: mouse    Sample: BMECs

Fig. 4. |The relationship between Fn and ITGB1 expression and S. aureus adhesion to BMECs treated with TGF-β1. A. TGF-β1 significantly promoted Fn expression as well as S. aureus adhesion to BMECs.B. TGF-β1 significantly promoted ITGB1 expression as well as S. aureus adhesion to BMECs. SPA is a surface protein of S. aureus that binds to IgG molecules by their Fc region.

Application: IHC    Species: mouse    Sample: acini and the surrounding connective tissue

Fig. 5.| TGF-β1 contributed to S. aureus colonization of mouse mammary glands and transfer into the bloodstream by promoting Fn and ITGB1 expression. E, F. TGF-β1 increased S. aureus-mediated damage to the mammary gland by promoting the expression of Fn and ITGB1 in damaged acini and the surrounding connective tissue. Fn and ITGB1, ABC method,counterstained with hematoxylin.

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