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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2719, RRID:AB_2839925.
展开/折叠
ALXR; FMLP-R-I; FMLP-R-II; FMLP-related receptor I; FMLPX; Formyl peptide receptor 2; Formyl peptide receptor related; Formyl peptide receptor-like 1; FPR2; FPR2_HUMAN; FPR2A; FPRH1; FPRH2; FPRL1; HM63; Lipoxin A4 receptor; LXA4 receptor; LXA4R; N-formyl peptide receptor 2; RFP;
抗原和靶标
Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
- P25090 FPR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P25090 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T196 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| Y302 | Phosphorylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| T319 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| T332 | Phosphorylation | Uniprot | |
| T335 | Phosphorylation | Uniprot |
研究背景
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).
Cell membrane>Multi-pass membrane protein.
Note: Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized.
Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
Interacts with Amyloid-beta protein 42, product of APP; the interaction takes place at the cell surface and the complex is then rapidly internalized.
(Microbial infection) Interacts with Staphylococcus aureus protein SSL13; this interaction leads to the activation of neutrophils.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.
文献引用
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