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| 产品: | 5HT1D Receptor 抗体 |
| 货号: | DF2706 |
| 描述: | Rabbit polyclonal antibody to 5HT1D Receptor |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Chicken |
| 分子量: | 45 kDa; 42kD(Calculated). |
| 蛋白号: | P28221 |
| RRID: | AB_2839912 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2706, RRID:AB_2839912.
展开/折叠
5 HT 1D alpha; 5 HT 1D; 5 HT1B; 5 HT1D; 5 hydroxytryptamine (serotonin) receptor 1B; 5 hydroxytryptamine (serotonin) receptor 1D G protein coupled; 5 hydroxytryptamine 1B receptor (5 HT 1B) (Serotonin receptor) (5 HT 1D beta) (Serotonin 1D beta receptor) (S12); 5 hydroxytryptamine receptor 1D; HT1DA; HTR1D; HTR1D2; HTR1DA; HTRL; RDC4; S12; Serotonin receptor 1D;
抗原和靶标
- P28221 5HT1D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P28221 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T61 | Phosphorylation | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| Y235 | Phosphorylation | Uniprot | |
| K280 | Ubiquitination | Uniprot |
研究背景
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Cell membrane>Multi-pass membrane protein.
Detected in brain neocortex and caudate nucleus (at protein level).
Homodimer. Heterodimer with HTR1B.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Nervous system > Serotonergic synapse.
· Organismal Systems > Sensory system > Taste transduction.
文献引用
Application: IHC Species: Mouse Sample: subcutaneous tumors
Application: WB Species: Mouse Sample:
限制条款
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