CIRBP Antibody - #DF2643

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产品: CIRBP 抗体
货号: DF2643
描述: Rabbit polyclonal antibody to CIRBP
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Bovine, Sheep, Dog, Chicken, Xenopus
蛋白号: Q14011
RRID: AB_2839849

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CIRBP Antibody detects endogenous levels of total CIRBP.
RRID:
AB_2839849
引用格式: Affinity Biosciences Cat# DF2643, RRID:AB_2839849.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

A18 hnRNP; A18HNRNP; cirbp; CIRBP_HUMAN; CIRP; Cold inducible RNA binding protein; Cold-inducible RNA-binding protein; Glycine rich RNA binding protein; Glycine-rich RNA-binding protein CIRP; testicular tissue protein Li 39;

抗原和靶标

免疫原:

A synthesized peptide derived from human CIRBP, corresponding to a region within C-terminal amino acids.

基因/基因ID:
CIRBP(1153)
描述:
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

文献引用

1). mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression. MEDIATORS OF INFLAMMATION, 2022 (PubMed: 35915740) [IF=4.4]

Application: WB    Species: Mouse    Sample:

Figure 6 CD4+ T cells were assessed for the expression of mTOR pathway-associated proteins, ERS-associated proteins, and apoptosis-associated proteins in WT, LCK-mTOR, LCK-TSC1, CLP, CLP+CIRP-Ab, CLP+NAC, LCK-TSC1+CLP, and Lck-mTOR+CLP mouse groups. Data are mean ± SD. Number of mice per group = 4 (one-way ANOVA Tukey's post hoc test). CD4+ T cells were purified from CIRP-Ab-treated mice, NAC-treated mice, TSC1 knockout mice, and mTOR mouse spleen lymphocytes. Total proteins were western blotted to identify the expression patterns of mTOR pathway proteins (P-mTOR, mTOR, p70s6k, p-p70s6k, P-4EBP, and 4EBP) (a); CIRP and ERS-associated proteins (GRP78 and CHOP) (b); and apoptosis-related proteins (caspase-3, Bax, and Bcl-2) (c).
2). The protective effect of C23 in a rat model of cardiac arrest and resuscitation. SHOCK, 2023 (PubMed: 36930651) [IF=2.7]
3). CIRBP Increases the synthesis and secretion of steroid hormones by in yak granulaso cells. The Journal of steroid biochemistry and molecular biology, 2024 (PubMed: 38143009) [IF=2.7]

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