SirT1 Antibody - #DF2622

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产品: SirT1 抗体
货号: DF2622
描述: Rabbit polyclonal antibody to SirT1
应用: WB
文献验证: WB
反应: Human, Mouse
蛋白号: Q96EB6
RRID: AB_2839828

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
SirT1 Antibody detects endogenous levels of total SirT1.
RRID:
AB_2839828
引用格式: Affinity Biosciences Cat# DF2622, RRID:AB_2839828.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

75SirT1; hSIR2; hSIRT1; HST2, S. cerevisiae, homolog of; NAD dependent deacetylase sirtuin 1; NAD dependent protein deacetylase sirtuin 1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; SIR1_HUMAN; SIR2; SIR2 like 1; SIR2 like protein 1; SIR2, S.cerevisiae, homolog-like 1; SIR2-like protein 1; SIR2ALPHA; SIR2L1; Sirt1; SirtT1 75 kDa fragment; Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); Sirtuin 1; Sirtuin type 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human SirT1, corresponding to a region within N-terminal amino acids.

基因/基因ID:
SIRT1(23411)

研究领域

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > FoxO signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > AMPK signaling pathway.   (View pathway)

· Human Diseases > Substance dependence > Amphetamine addiction.

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

· Organismal Systems > Aging > Longevity regulating pathway.   (View pathway)

· Organismal Systems > Aging > Longevity regulating pathway - multiple species.   (View pathway)

· Organismal Systems > Endocrine system > Glucagon signaling pathway.

文献引用

1). Inonotsuoxide B regulates M1 to M2 macrophage polarization through sirtuin-1/endoplasmic reticulum stress axis. International Immunopharmacology, 2021 (PubMed: 33831807) [IF=4.8]

Application: WB    Species: mouse    Sample: RAW264.7 cells

Fig. 3. Inonotsuoxide B (IB) decreased endoplasmic reticulum stress (ERS)-related 78-kDa glucose-regulated protein (GRP78) and inositol-requiring enzyme 1α (IRE1α) mRNA and protein expression and increased sirtuin 1 (SIRT1) mRNA and protein expression in RAW264.7 cells exposed to lipopolysaccharide (LPS). (A) Sirt1, Grp78, and Ire1α mRNA levels were analyzed using quantitative real-time polymerase chain reaction (PCR). (B) SIRT1, GRP78, and IRE1α protein levels were analyzed using western blotting. Western blot bands were from same membrane. Histogram shows control, LPS, and LPS + 5 μg/mL IB. Values are the mean ± standard error of the mean (SEM) of a minimum of three independent experiments. *P < 0.05 and **P < 0.01 compared with control group; #P < 0.05 and ##P < 0.01 compared with LPS group.

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