产品: CITED2 抗体
货号: DF2455
描述: Rabbit polyclonal antibody to CITED2
应用: WB IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Dog, Chicken
蛋白号: Q99967
RRID: AB_2839661

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CITED2 Antibody detects endogenous levels of total CITED2.
RRID:
AB_2839661
引用格式: Affinity Biosciences Cat# DF2455, RRID:AB_2839661.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ASD8; Cbp/p300 interacting transactivator 2; Cbp/p300 interacting transactivator with Glu/Asp rich carboxy terminal domain 2; Cbp/p300-interacting transactivator 2; CITE2_HUMAN; CITED 2; CITED2; melanocyte-specific gene 1-related gene 1; MRG 1; MRG-1; MRG1; MSG related protein 1; MSG-related protein 1; MSG1-related gene 1; P35srj; VSD2;

抗原和靶标

免疫原:

A synthesized peptide derived from human CITED2, corresponding to a region within the internal amino acids.

基因/基因ID:
描述:
Interferes with the binding of transcription factors HIF-1a and STAT2 to p300/CBP.

文献引用

1). Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration. Journal of biological engineering, 2024 (PubMed: 38254196) [IF=5.7]

Application: WB    Species: human    Sample:

Fig. 6 Gene expression changes in nucleus pulposus cells treated with each experimental group for 48 hours were detected using RT-qPCR. (B) Western bolt showed protein expression levels in different experimental groups.Mean ± SD represents all the statistical data. The significance levels are denoted as follows: (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns indicates that the difference is not statistically significant)

2). CITED2 Mediates Metabolic Reprogramming in Renal Tubular Epithelial Cells via the AKT Signaling Pathway to Induce Sepsis-Associated Acute Kidney Injury. Journal of inflammation research, 2024 (PubMed: 39600684) [IF=4.5]

Application: IF/ICC    Species: Mouse    Sample:

Figure 1 Impairment of kidney structure and function in septic mice, characterized by macrophage infiltration and elevated CITED2 expression. (A-C). Serum expression levels of IL-1β, IL-6, and TNF-α in the Sham and Sepsis groups. (D and E). Serum levels of UREA and CREA in the Sham and Sepsis groups. (F and G). Gene expression levels of kidney injury markers (KIM-1 and NGAL) in kidney tissues of the Sham and Sepsis groups. H. HE staining of renal tissues in the Sham and Sepsis groups. (I). PAS staining of renal tissues in both Sham and Sepsis groups. (J). Protein and gene expression levels of CITED2 in renal tissues of the Sham and Sepsis groups. (K). Immunofluorescence staining for CITED2 and F4/80 in renal tissues of the Sham and Sepsis groups. *P < 0.05, **P < 0.01, ***P < 0.001. Significance indicators: ns (no significant difference).

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