CXCR6 Antibody - #DF2328

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产品: CXCR6 抗体
货号: DF2328
描述: Rabbit polyclonal antibody to CXCR6
应用: WB IHC
文献验证: IHC
反应: Human, Mouse, Rat
预测: Rabbit, Dog
蛋白号: O00574
RRID: AB_2839552

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:100
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CXCR6 Antibody detects endogenous levels of total CXCR6.
RRID:
AB_2839552
引用格式: Affinity Biosciences Cat# DF2328, RRID:AB_2839552.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

C X C chemokine receptor type 6; C-X-C chemokine receptor type 6; CD 186; CD186; CD186 antigen; CDw186; Chemokine (C X C motif) receptor 6; Chemokine C X C motif receptor 6; Chemokine CXC motif receptor 6; Chemokine receptor 6; CXC chemokine receptor type 6; CXC R6; CXC-R6; CXCR 6; CXCR-6; CXCR6; CXCR6_HUMAN; G protein coupled receptor; G protein coupled receptor bonzo; G protein coupled receptor STRL 33; G protein coupled receptor STRL33; G protein coupled receptor TYMSTR; G-protein coupled receptor bonzo; G-protein coupled receptor STRL33; STRL 33; STRL33; TYMSTR;

抗原和靶标

免疫原:

A synthesized peptide derived from human CXCR6, corresponding to a region within C-terminal amino acids.

基因/基因ID:
CXCR6(10663)
描述:
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Organismal Systems > Immune system > Chemokine signaling pathway.   (View pathway)

文献引用

1). CXCL16/CXCR6/TGF-β Feedback Loop Between M-MDSCs and Treg Inhibits Anti-Bacterial Immunity During Biofilm Infection. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025 (PubMed: 39716908) [IF=15.1]

Application: IHC    Species: Mouse    Sample:

Figure 5 PJI patients with high CXCR6 showed a higher recurrence rate. a) The Volcano plot showed differentially expressed genes in PJI versus AF patients. The x and y axes represented the log2 fold change and p-value, respectively, based on the Mann-Whitney U test. Red dots: upregulated genes, blue dots: downregulated genes. b) The heatmap showed the distribution of 28 types of immune cells in PJI and AF. c) The bar chart showed the difference in proportion of M-MDSCs and Treg between PJI and AF (PJI, n = 18; AF, n = 18). Unpaired t test; ***p < 0.001. d) The heatmap showed the characteristic genes of chemokines, PJI markers, cell markers and immune checkpoint between PJI and AF. e–l) The violin plots showed part of the differential genes (CXCL16, CXCR6, S100A8, S100A9, FOXP3, CTLA4, TIGIT and LAG3) between PJI and AF as shown in (d). Unpaired t test; nsp > 0.05, ***p < 0.001, ****p < 0.0001. m,n) Quantitative analysis of immunohistochemical staining for CXCL16 and CXCR6 (PJI, n = 80; AF, n = 25; OA = 25). 40x magnification. Scale bar, 20 mm. Unpaired t test; **p < 0.01, ***p < 0.001. o) The Kaplan-Meier curve showed the recurrence curves of PJI patients characterized by either low or high expression of CXCR6 (CXCR6-high PJI, n = 30; CXCR6-low PJI, n = 30). Significance was calculated using the log-rank test. p,q) Quantitative analysis of Harris Hip score and HSS knee score in CXCR6-high PJI and CXCR6-low PJI group (CXCR6-high PJI, n = 30; CXCR6-low PJI, n = 30). Unpaired t test
2). Targeting of Tumoral NAC1 Mitigates Myeloid-Derived Suppressor Cell-Mediated Immunosuppression and Potentiates Anti-PD-1 Therapy in Ovarian Cancer. Cancer immunology research, 2025 (PubMed: 39531476) [IF=8.1]

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