CD2AP Antibody - #DF2298

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产品: CD2AP 抗体
货号: DF2298
描述: Rabbit polyclonal antibody to CD2AP
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: Q9Y5K6
RRID: AB_2839524

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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实验方案
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CD2AP Antibody detects endogenous levels of total CD2AP.
RRID:
AB_2839524
引用格式: Affinity Biosciences Cat# DF2298, RRID:AB_2839524.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Adapter protein CMS; AL024079; C78928; Cas ligand with multiple SH3 domains; CD2 associated protein; CD2-associated protein; CD2AP; CD2AP_HUMAN; CMS; Mesenchyme to epithelium transition protein with SH3 domains 1; METS 1; Mets1;

抗原和靶标

免疫原:

A synthesized peptide derived from human CD2AP, corresponding to a region within the internal amino acids.

基因/基因ID:
CD2AP(23607)
描述:
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis

研究领域

· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.

文献引用

1). ADAM metallopeptidase domain 10 knockdown enables podocytes to resist high glucose stimulation by inhibiting pyroptosis via MAPK pathway. Experimental and Therapeutic Medicine, 2023 (PubMed: 37153901) [IF=2.4]

Application: WB    Species: Mouse    Sample:

Figure 2 ADAM10 knockdown inhibits HG-induced podocyte apoptosis. (A) Podocyte markers were evaluated using western blot analysis. (B) Podocyte apoptosis was evaluated using the TUNEL assay. (C) Apoptotic rate was obtained according to the results of the TUNEL assay. (D) Expression levels of proteins related to apoptosis were assessed using western blot analysis. ***P
2). The Yi-Qi-Bu-Shen recipe attenuates high glucose-induced podocyte injury via the inhibition of IKK-IκBα-NFκB and ERK/P38 MAPK signaling . International Journal of Clinical and Experimental Medicine, 2022 [IF=0.2]

Application: WB    Species: Human    Sample: podocytes

Figure 2. Effect of YB on HG-induced expression of nephrin, podocin and CD2AP in podocytes. A-C. Podocytes were treated with HG and YB for 24 hours and then mRNA levels of nephrin, podocin and CD2AP were determined by qRT-PCR. (*P

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