| 产品: | GPSN2 抗体 |
| 货号: | DF2247 |
| 描述: | Rabbit polyclonal antibody to GPSN2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Dog, Chicken, Xenopus |
| 分子量: | 36 kDa; 36kD(Calculated). |
| 蛋白号: | Q9NZ01 |
| RRID: | AB_2839478 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2247, RRID:AB_2839478.
展开/折叠
2410016D23Rik; A230102P12Rik; AI173355; D17Ertd178e; Glycoprotein synaptic 2; Gpsn2; Neuroprotective protein 13; SC2; Synaptic glycoprotein SC2; Tecr; TER; Trans 2,3 enoyl CoA reductase;
抗原和靶标
- Q9NZ01 TECR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NZ01 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K2 | Acetylation | Uniprot | |
| K2 | Ubiquitination | Uniprot | |
| Y4 | Phosphorylation | Uniprot | |
| K12 | Acetylation | Uniprot | |
| K12 | Ubiquitination | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| K22 | Acetylation | Uniprot | |
| K22 | Ubiquitination | Uniprot | |
| T28 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| K60 | Acetylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| T145 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot |
研究背景
Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA.
Glycosylated.
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Expressed in most tissues tested. Highly expressed in skeletal muscle.
Interacts with ELOVL1 and LASS2.
Belongs to the steroid 5-alpha reductase family.
研究领域
· Metabolism > Lipid metabolism > Fatty acid elongation.
· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.
· Metabolism > Global and overview maps > Fatty acid metabolism.
限制条款
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