53BP1 Antibody - #DF7472

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产品: 53BP1 抗体
货号: DF7472
描述: Rabbit polyclonal antibody to 53BP1
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Horse, Sheep, Rabbit, Dog
蛋白号: Q12888
RRID: AB_2839409

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
53BP1 Antibody detects endogenous levels of total 53BP1.
RRID:
AB_2839409
引用格式: Affinity Biosciences Cat# DF7472, RRID:AB_2839409.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

53 BP1; 53BP1; FLJ41424; MGC138366; p202; p53 binding protein 1; p53 BP1; p53-binding protein 1; p53BP1; TP53 BP1; TP53B_HUMAN; Tp53bp1; TRP53 BP1; Tumor protein 53 binding protein 1; Tumor protein p53 binding protein 1; Tumor suppressor p53 binding protein 1; Tumor suppressor p53-binding protein 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human 53BP1, corresponding to a region within N-terminal amino acids.

基因/基因ID:
TP53BP1(7158)

研究领域

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

文献引用

1). PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer. Journal of translational medicine, 2023 (PubMed: 37415147) [IF=7.4]

Application: WB    Species: Human    Sample: PC3 cells

Fig. 5. Olaparib combined with ML216 has a better effect in enhancing total DNA damage. A–D IF staining showing the expression of γH2AX and 53BP1 in PC3 cells treated with ML216 (8 μM) and olaparib (50 μM), ML216 or olaparib monotherapy, or DMSO for 48 h. Scale bars: 25 μm. E Comet assay of PC3 cells treated with ML216 (8 μM) and olaparib (50 μM), ML216 or olaparib monotherapy, or DMSO for 48 h.The olive tail moment was used as an index and was statistically analyzed. Scale bars: 20 μm. F–G Western blot analysis of the expression of proteins involved in the HR and NHEJ pathways in PC3 cells treated with ML216 (8 μM) and olaparib (50 μM), ML216 or olaparib monotherapy, or DMSO for 48 h. Scale bars: 20 μm. Shown are the means ± SD from 3 experiments (*P 

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