SLC3A2 Antibody - #DF7468

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产品: SLC3A2 抗体
货号: DF7468
描述: Rabbit polyclonal antibody to SLC3A2
应用: WB IHC
文献验证:
反应: Human, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: P08195
RRID: AB_2839405

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Rat
克隆:
Polyclonal
特异性:
SLC3A2 Antibody detects endogenous levels of total SLC3A2.
RRID:
AB_2839405
引用格式: Affinity Biosciences Cat# DF7468, RRID:AB_2839405.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

4F2; 4F2 cell surface antigen heavy chain; 4F2 cell-surface antigen heavy chain; 4F2 heavy chain; 4F2 heavy chain antigen; 4F2_HUMAN; 4F2hc; 4T2HC; Antigen defined by monoclonal antibody 4F2 heavy chain; Antigen identified by monoclonal antibodies 4F2 TRA1.10 TROP4 and T43; CD 98; CD98; CD98 antigen; CD98 heavy chain; CD98HC; Heavy chain; Lymphocyte activation antigen 4F2 large subunit; MDU 1; MDU1; Monoclonal antibody 44D7; NACAE; Slc3a2; Solute carrier family 3 (activators of dibasic and neutral amino acid transport) member 2; Solute carrier family 3 member 2;

抗原和靶标

免疫原:

A synthesized peptide derived from human SLC3A2, corresponding to a region within the internal amino acids.

基因/基因ID:
SLC3A2(6520)
描述:
This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.

研究领域

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

· Environmental Information Processing > Signal transduction > mTOR signaling pathway.   (View pathway)

· Organismal Systems > Digestive system > Protein digestion and absorption.

文献引用

1). Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization. Cancer letters, 2024 (PubMed: 38360142) [IF=9.1]
2). The mechanism of the imbalance between proliferation and ferroptosis in pulmonary artery smooth muscle cells based on the activation of SLC7A11. European Journal of Pharmacology, 2022 (PubMed: 35700835) [IF=4.2]
3). Identification and analysis of a prognostic ferroptosis and iron-metabolism signature for esophageal squamous cell carcinoma. Journal of Cancer, 2023 (PubMed: 35371305) [IF=3.3]

Application: IF/ICC    Species: Human    Sample: ESCC

Figure 4 Immunofluorescence of PRNP (green), SLC39A8 (red), LCN2 (red), ATP6V0A1 (green), SLC3A2 (red), and SLC39A14 (green) in ESCC samples and normal tissues.
4). Integrated analysis of FKBP1A/SLC3A2 axis in everolimus inducing ferroptosis of breast cancer and anti-proliferation of T lymphocyte. International journal of medical sciences, 2023 (PubMed: 37484811) [IF=3.2]

Application: IF/ICC    Species: human    Sample: breast cancer

Figure 1. SLC3A2 localization, expression and association with breast cancer. A SLC3A2 protein localization showed plasma membrane and nucleoplasm. B SLC3A2 protein topology showed crossing cell membrane once. C Immunofluorescence staining of the subcellular distribution of SLC3A2 in A-431, SiHa, and U-2 OS cells as adopted from the HPA database. Scale bar = 5 um. D The mRNA levels of SLC3A2 in different types of human cancers from TIMER2 database. E Disease network interaction analysis of SLC3A2 from OPENTARGET database. F The mRNA level of SLC3A2 in breast cancer from UALCAN database. G Immunohistochemistry analysis of SLC3A2 in breast cancer from HPA database. *p

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