RNF2 Antibody - #DF7403

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产品: RNF2 抗体
货号: DF7403
描述: Rabbit polyclonal antibody to RNF2
应用: WB IHC
文献验证: IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
蛋白号: Q99496
RRID: AB_2839341

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
RNF2 Antibody detects endogenous levels of total RNF2.
RRID:
AB_2839341
引用格式: Affinity Biosciences Cat# DF7403, RRID:AB_2839341.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

BAP 1; BAP1; DING; DinG protein; E3 ubiquitin protein ligase RING 2; E3 ubiquitin protein ligase RING2; E3 ubiquitin-protein ligase RING2; HIP2 interacting protein 3; HIP2-interacting protein 3; HIPI 3; HIPI3; Huntingtin interacting protein 2 interacting protein 3; Huntingtin-interacting protein 2-interacting protein 3; OTTHUMP00000060668; Polycomb M33 interacting protein Ring 1B; Polycomb M33 interacting protein Ring1B; Protein DinG; RING 1B; RING 2; RING finger protein 1B; RING finger protein 2; RING finger protein BAP 1; RING finger protein BAP-1; RING finger protein BAP1; RING1b; RING2_HUMAN; RNF 2; Rnf2;

抗原和靶标

免疫原:

A synthesized peptide derived from human RNF2, corresponding to a region within the internal amino acids.

基因/基因ID:
RNF2(6045)
描述:
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.

文献引用

1). GNPNAT1 Predicts Poor Prognosis and Cancer Development in Non-Small Cell Lung Cancer. Cancer Management and Research, 2022 (PubMed: 35975106) [IF=2.5]

Application: IHC    Species: Human    Sample: lung cancer cell

Figure 4 Aberrant TFs contributed to the upregulation of GNPNAT1 in NSCLC. (A) RNF2, ZNF143, RAD21, and YY1 were the intersecting TFs from the top ten TFs most correlated with GNPNAT1 in the four groups. (B) The four TFs were highly positively correlated with GNPNAT1 in LUAD and LUSC tissues. (C) RNF2 mRNA was increased in LUAD and LUSC tissues. (D) IHC assays indicated that RNF2 located in both cytoplasm and nucleus of lung cancer cells. (E) The nucleic RNF2 was not statistically different between LUAD and LUSC. (F) The nucleic RNF2 was positively correlated with GNPNAT1 in NSCLC. * P<0.05.

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