VAPB Antibody - #DF7303

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产品: VAPB 抗体
货号: DF7303
描述: Rabbit polyclonal antibody to VAPB
应用: WB IHC
反应: Human, Mouse, Rat
分子量: 27kDa; 27kD(Calculated).
蛋白号: O95292
RRID: AB_2839241

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
VAPB Antibody detects endogenous levels of total VAPB.
RRID:
AB_2839241
引用格式: Affinity Biosciences Cat# DF7303, RRID:AB_2839241.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ALS 8; ALS8; D2Abb2e; UNQ484/PRO983; Vamp 33b; VAMP associated 33 kDa protein; VAMP associated protein B and C; VAMP associated protein B; VAMP associated protein B/C; VAMP associated protein C; VAMP B; VAMP B VAMP C; VAMP B/VAMP C; VAMP C; VAMP vesicle associated membrane protein associated protein B and C; Vamp33b; VAMPB; VAMPB/VAMPC; VAMPC; VAP 33b; VAP B; VAP B/VAP C; VAP C; VAP33b; VAPB/VAPC; VAPC; Vesicle associated membrane protein associated protein B and C; Vesicle associated membrane protein associated protein B/C;

抗原和靶标

免疫原:
Uniprot:

O95292(VAPB_HUMAN) >>Visit HPA database.

基因/基因ID:
VAPB(9217)
表达:
O95292 VAPB_HUMAN:

Ubiquitous. Isoform 1 predominates.

描述:
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
序列:
MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL

翻译修饰 - O95292 作为底物

Site PTM Type Enzyme
A2 Acetylation
K3 Acetylation
K3 Ubiquitination
S9 Phosphorylation
K17 Ubiquitination
T23 Phosphorylation
T27 Phosphorylation
T28 Phosphorylation
R38 Methylation
K43 Methylation
K118 Acetylation
K118 Ubiquitination
K131 Ubiquitination
K139 Ubiquitination
S142 Phosphorylation
T143 Phosphorylation
S146 Phosphorylation
K147 Acetylation
K147 Sumoylation
K147 Ubiquitination
T150 Phosphorylation
S154 Phosphorylation
K155 Ubiquitination
S156 Phosphorylation
S158 Phosphorylation
S159 Phosphorylation
S160 Phosphorylation
T164 Phosphorylation
K188 Ubiquitination
T201 Phosphorylation
S204 Phosphorylation
S206 Phosphorylation
S209 Phosphorylation
T214 Phosphorylation
K216 Acetylation
S221 Phosphorylation
T222 Phosphorylation

研究背景

功能:

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

细胞定位:

Endoplasmic reticulum membrane>Single-pass type IV membrane protein.
Note: Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous. Isoform 1 predominates.

亚基结构:

Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27. Interacts with RMDN3. Interacts with KIF5A in a ZFYVE27-dependent manner. Interacts with STARD3 (via FFAT motif). Interacts with STARD3NL (via FFAT motif). Interacts with CERT1.

(Microbial infection) Interacts with HCV protein NS5A and NS5B.

蛋白家族:

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

研究领域

· Organismal Systems > Digestive system > Cholesterol metabolism.

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