SMARCE1 Antibody - #DF7301

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产品: SMARCE1 抗体
货号: DF7301
描述: Rabbit polyclonal antibody to SMARCE1
应用: WB IHC IF/ICC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Pig, Horse, Sheep, Rabbit, Dog
蛋白号: Q969G3
RRID: AB_2839239

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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实验方案
WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
SMARCE1 Antibody detects endogenous levels of total SMARCE1.
RRID:
AB_2839239
引用格式: Affinity Biosciences Cat# DF7301, RRID:AB_2839239.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

BAF57; BRG1 associated factor 57; BRG1-associated factor 57; Chromatin remodeling complex BRG1 associated factor 57; FLJ35648; SMARCE 1; SMARCE1; SMCE1_HUMAN; SWI/SNF related matrix associated actin dependent regulator of chromatin e1; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human SMARCE1, corresponding to a region within C-terminal amino acids.

基因/基因ID:
SMARCE1(6605)
描述:
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.

研究领域

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

文献引用

1). High expression of SMARCE1 predicts poor prognosis and promotes cell growth and metastasis in gastric cancer. Cancer Management and Research, 2019 (PubMed: 31118775) [IF=2.5]

Application: WB    Species: human    Sample: T and NT tissues

Figure 1 |SMARCE1 is upregulated in GC tissues.(A and B) the mRNA expression of SMARCE1 was significantly higher in GC tissues than in normal tissues according to TCGA data and Oncomine dataset . (C) The mRNA expression of SMARCE1 was measured in 20 paired fresh human GC tissues (T) and matched adjacent nontumor tissues (NT). (D) The protein expression of SMARCE1 in eight randomly selected paired T and NT tissues was examined using western blotting. β-actin was used as a control.

Application: IHC    Species: human    Sample: 122 paired NT and human GC samples

Figure 2 |Elevated SMARCE1 expression indicates poor prognosis in GC patients.(A) Representative image of SMARCE1 immunohistochemical staining in 122 paired NT and human GC samples. Up: magnification ×100; down: magnification x400

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