| 产品: | BPI 抗体 |
| 货号: | DF7282 |
| 描述: | Rabbit polyclonal antibody to BPI |
| 应用: | WB IHC |
| 反应: | Human, Rat |
| 分子量: | 54kDa; 54kD(Calculated). |
| 蛋白号: | P17213 |
| RRID: | AB_2839221 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7282, RRID:AB_2839221.
展开/折叠
Bactericidal permeability-increasing protein; bactericidal/permeability-increasing protein; BPI; BPI fold containing family D, member 1; BPIFD1; CAP 57; rBPI; recombinant BPI holoprotein, rBPI;
抗原和靶标
- P17213 BPI_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRENMARGPCNAPRWASLMVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
研究背景
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Secreted. Cytoplasmic granule membrane.
Note: Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Restricted to cells of the myeloid series.
Monomer. Homodimer; disulfide-linked.
The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
限制条款
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