UTS2 Antibody - #DF7281

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产品: UTS2 抗体
货号: DF7281
描述: Rabbit polyclonal antibody to UTS2
应用: WB IHC
文献验证: WB
反应: Human, Rat
分子量: 14kDa; 14kD(Calculated).
蛋白号: O95399
RRID: AB_2839220

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Rat
克隆:
Polyclonal
特异性:
UTS2 Antibody detects endogenous levels of total UTS2.
RRID:
AB_2839220
引用格式: Affinity Biosciences Cat# DF7281, RRID:AB_2839220.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

PRO1068; U-II; UCN2; UII; Urotensin 2 preproprotein isoform a; Urotensin 2 preproprotein isoform b; Urotensin II; Urotensin-2; UTS2; UTS2_HUMAN; UTSII;

抗原和靶标

免疫原:
Uniprot:

O95399(UTS2_HUMAN) >>Visit HPA database.

基因/基因ID:
UTS2(10911)
表达:
O95399 UTS2_HUMAN:

Brain specific.

描述:
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.
序列:
MYKLASCCLLFIGFLNPLLSLPLLDSREISFQLSAPHEDARLTPEELERASLLQILPEMLGAERGDILRKADSSTNIFNPRGNLRKFQDFSGQDPNILLSHLLARIWKPYKKRETPDCFWKYCV

研究背景

功能:

Highly potent vasoconstrictor.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Brain specific.

蛋白家族:

Belongs to the urotensin-2 family.

文献引用

1). Urantide prevents CCl4‑induced acute liver injury in rats by regulating the MAPK signalling pathway. Molecular Medicine Reports, 2021 (PubMed: 34328202) [IF=3.4]

Application: WB    Species: Rat    Sample: liver tissue

Figure 3. Expression levels of UII and GPR14 in ALI livers was attenuated following urantide administration. Relative (A and B) gene (C) and protein expression levels of UII and GPR14 were measured via RT-qPCR and western blotting, respectively. Relative protein expression of (D) UII and (E) GPR14. The data are presented as the mean ± SEM. For RT-qPCR, western blotting and morphological analysis, n=6 per group. *P<0.05 and **P<0.01 vs. control; ^^P<0.01 vs. ALI model; #P<0.05 and ##P<0.01 vs. MgIG. UII, urotensin II; GPR14, receptor G protein-coupled receptor 14; RT-qPCR, reverse transcription PCR; MgIG, magnesium isoglycyrrhizinate; ALI, ALI, acute liver injury.
2). Urantide alleviates atherosclerosis-related liver and kidney injury via the Wnt/β-catenin signaling pathway in ApoE(-/-) mice. Herz, 2024 (PubMed: 37985514) [IF=1.1]
3). Urantide alleviates atherosclerosis-related liver and kidney injury via the Wnt/β-catenin signaling pathway in ApoE(-/-) mice. Herz, 2023 (PubMed: 37985514) [IF=1.1]

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