AIF1/IBA1 Antibody - #DF7217

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产品: AIF1/IBA1 抗体
货号: DF7217
描述: Rabbit polyclonal antibody to AIF1/IBA1
应用: WB IHC IF/ICC
文献验证: IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit
蛋白号: P55008
RRID: AB_2839160

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IHC 1:50-1:100, IF/ICC 1:100-500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
AIF1/IBA1 Antibody detects endogenous levels of total AIF1/IBA1.
RRID:
AB_2839160
引用格式: Affinity Biosciences Cat# DF7217, RRID:AB_2839160.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AIF 1; AIF-1; Aif1; AIF1 protein; AIF1_HUMAN; Allograft inflammatory factor 1; Allograft inflammatory factor 1 splice variant G; allograft inflammatory factor-1 splice variant Hara-1; balloon angioplasty responsive transcription; BART 1; G1; G1 putative splice variant of allograft inflamatory factor 1; IBA 1; IBA1; interferon gamma responsive transcript; Interferon responsive transcript 1; interferon responsive transcript factor 1; Ionized calcium binding adapter molecule 1; Ionized calcium-binding adapter molecule 1; ionized calcium-binding adapter molecule; IRT 1; IRT1; Microglia response factor; MRF1; Protein g1;

抗原和靶标

免疫原:

A synthesized peptide derived from human AIF1/IBA1, corresponding to a region within C-terminal amino acids.

基因/基因ID:
AIF1(199)
描述:
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene.

文献引用

1). Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation. Biomedicine & Pharmacotherapy, 2022 (PubMed: 35772378) [IF=6.9]

Application: IF/ICC    Species: Mouse    Sample: BV2 cells

Fig. 3. Effects of stigmasterol treatment on Aβ42 oligomers induced inflammatory response in BV2 cells. (A) Cell viability after Aβ42 oligomers treatment. (B-D) Concentration of TNFα, IL-1β and IL-10 after Aβ42 oligomers treatment. (E) Cell viability after stigmasterol treatment. (F, H) Concentration of TNFα, IL-1β and IL-10 after Aβ42 oligomers and stigmasterol treatment. (I) Representative images of CD86 expression in BV2 cells, measured by flow cytometry. (J) Quantification of CD86+ cells. (K) Representative images of immunofluorescence staining for Iba1 (red) in BV2 cells. Scale bar 40 µm. (L, M) Cell counts and quantification of Iba1 fluorescence intensity. Data were presented as the mean ± SEM from three independent experiments. One-way ANOVA with Tukey’s multiple comparison test revealed a difference between groups. *P 
2). Melatonin suppresses inflammation and blood‒brain barrier disruption in rats with vascular dementia possibly by activating the SIRT1/PGC-1α/PPARγ signaling pathway. Inflammopharmacology, 2023 (PubMed: 37017851) [IF=4.6]
3). Luteolin and Exercise Combination Therapy Ameliorates Amyloid-β1-42 Oligomers-Induced Cognitive Impairment in AD Mice by Mediating Neuroinflammation and Autophagy. Journal of Alzheimer's disease : JAD, 2023 (PubMed: 36710678) [IF=3.4]
4). Systematic analysis of critical genes and pathways identified a signature of neuropathic pain after spinal cord injury. European Journal of Neuroscience, 2022 (PubMed: 35560852) [IF=2.7]
5). Cinnamaldehyde Attenuates the Expression of IBA1 and GFAP to Inhibit Glial Cell Activation and Inflammation in the MPTP-Induced Acute Parkinson's Disease Model. Parkinson's disease, 2024 (PubMed: 39741957) [IF=2.1]

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