产品描述
来源:
Rabbit
应用:
WB 1:500-1:1000, IHC 1:20-1:50
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
PIWIL2 Antibody detects endogenous levels of total PIWIL2.
RRID:
AB_2839124
引用格式: Affinity Biosciences Cat# DF7172, RRID:AB_2839124.
引用格式: Affinity Biosciences Cat# DF7172, RRID:AB_2839124.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:
展开/折叠
Cancer/testis antigen 80; CT80; Hiwi like; MILI; Miwi like; Piwi like 2; Piwi-like protein 2; Piwil2; PIWL2_HUMAN;
抗原和靶标
免疫原:
A synthesized peptide derived from human PIWIL2, corresponding to a region within C-terminal amino acids.
基因/基因ID:
描述:
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.
限制条款
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