TERT Antibody - #DF7129

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产品: TERT 抗体
货号: DF7129
描述: Rabbit polyclonal antibody to TERT
应用: WB IHC IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Dog
蛋白号: O14746
RRID: AB_2839083

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
TERT Antibody detects endogenous levels of total TERT.
RRID:
AB_2839083
引用格式: Affinity Biosciences Cat# DF7129, RRID:AB_2839083.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CMM9; DKCA2; DKCB4; EST2; HEST2; htert; hTRT; PFBMFT1; TCS1; Telomerase associated protein 2; Telomerase catalytic subunit; Telomerase reverse transcriptase; Telomerase-associated protein 2; Telomere Reverse Transcriptase; TERT; TERT_HUMAN; TP2; TRT;

抗原和靶标

免疫原:

A synthesized peptide derived from human TERT

基因/基因ID:
TERT(7015)
描述:
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

研究领域

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

· Human Diseases > Cancers: Specific types > Gastric cancer.   (View pathway)

文献引用

1). Inhibition of hTERT/telomerase/telomere mediates therapeutic efficacy of osimertinib in EGFR mutant lung cancer. The Journal of experimental medicine, 2024 (PubMed: 39297884) [IF=12.6]
2). Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD). Journal of orthopaedic translation, 2023 (PubMed: 36909862) [IF=5.9]
3). The hTERT and iCasp9 Transgenes Affect EOMES and T-BET Levels in NK Cells and the Introduction of Both Genes Improves NK Cell Proliferation in Response to IL2 and IL15 Stimulation. Biomedicines, 2024 (PubMed: 38540262) [IF=4.7]
4). Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway. Molecules (Basel, Switzerland), 2024 (PubMed: 38202844) [IF=4.6]
5). Shugan Tongluo Qiangjing recipe protects against varicocele of EVC rats through modulating sperm DNA damage, telomere expression and oxidative stress. Tissue & cell, 2024 (PubMed: 38865824) [IF=2.7]
6). CDK4 and TERT amplification in head and neck mucosal melanoma. Journal of Oral Pathology & Medicine, 2021 (PubMed: 33797827) [IF=2.7]
7). Expression profiles of stemness genes in gastrointestinal stromal tumor. HUMAN PATHOLOGY, 2018 (PubMed: 29486292) [IF=2.7]
8). Senescence-related signatures predict prognosis and response to immunotherapy in colon cancer. Journal of gastrointestinal oncology, 2024 (PubMed: 38989417) [IF=2.0]
9). Wnt/PCP-YAP-BIRC2 axis maintains cartilage stem/progenitor cell homeostasis in osteoarthritis. Research Square, 2022

Application: WB    Species: Human    Sample: CSPCs

Figure 3. Wnt5A/B upregulates YAP in OA-CSPCs. a The mRNA expression of the genes associated with stem cell function in OA-CSPCs. b The protein levels of YAP, FAP, VDR, TERT, and MMP3 in OA-CSPCs. c Immunofluorescence staining of YAP (red) in OA-CSPCs. Nuclei were stained by 4,6-diamidina-2-phenylin (DAPI,blue), Bars=100 μm. d The protein levels of YAP in OA-CSPCs derived from OA patients.
10). Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase. Oncotarget, 2016 (PubMed: 27283992)

Application: WB    Species: rat    Sample:

(B ) and (C) Western blotting analysis was used to evaluate TERT protein level in cells.

Application: IF/ICC    Species: rat    Sample:

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