PTGER2 Antibody - #DF7107

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产品: PTGER2 抗体
货号: DF7107
描述: Rabbit polyclonal antibody to PTGER2
应用: WB IHC
文献验证: IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: P43116
RRID: AB_2839061

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
PTGER2 Antibody detects endogenous levels of total PTGER2.
RRID:
AB_2839061
引用格式: Affinity Biosciences Cat# DF7107, RRID:AB_2839061.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EP2; PE2R2_HUMAN; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostaglandin E receptor 2 EP2 subtype; Prostaglandin E receptor 2 subtype EP2 53kDa; Prostaglandin E receptor 2 subtype EP2; Prostaglandin E2 receptor; Prostaglandin E2 receptor EP2 subtype; Prostanoid EP2 receptor; Ptger2;

抗原和靶标

免疫原:

A synthesized peptide derived from human PTGER2, corresponding to a region within the internal amino acids.

基因/基因ID:
PTGER2(5732)
描述:
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. Prostaglandin E2 receptor (53kDa), also known as EP2, is a prostaglandin receptor for prostaglandin E2. It is encoded by the human gene PTGER2. Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

研究领域

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels.   (View pathway)

· Organismal Systems > Endocrine system > Renin secretion.

文献引用

1). Multifunctional injectable microspheres for osteoarthritis therapy via spatiotemporally modulating macrophage polarization and inflammation. NPJ Regenerative medicine, 2024 (PubMed: 39289387) [IF=7.2]

Application: IHC    Species: Rat    Sample:

Fig. 6: The result of immunohistochemistry and immunofluorescence staining. a Immunohistochemical analysis of TNF-α, COL2, AGGRECAN, PGE2, IL-10 expression in cartilage and synovium. Scale bar, 50 microns. b Quantitative immunohistochemistry analysis (n = 3). c Macrophages were detected by co-immunofluorescence staining for CD206 (green, anti-inflammatory)/CD68 (red, pan-macrophage), and iNOS (green, pro-inflammatory)/CD68 (red, pan-macrophage). Scale bars: 50 μm. d Quantification of CD68, CD206 and iNOS-positive cells (n = 5). Data are presented as means ± SD in (b, e).

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