CPT2 Antibody - #DF7089

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产品: CPT2 抗体
货号: DF7089
描述: Rabbit polyclonal antibody to CPT2
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: P23786
RRID: AB_2839044

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:100, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CPT2 Antibody detects endogenous levels of total CPT2.
RRID:
AB_2839044
引用格式: Affinity Biosciences Cat# DF7089, RRID:AB_2839044.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Carnitine O palmitoyltransferase 2; Carnitine O palmitoyltransferase 2 mitochondrial; Carnitine O-palmitoyltransferase 2; Carnitine palmitoyltransferase 2; Carnitine palmitoyltransferase II; CPT 1; CPT 2; CPT II; CPT1; CPT2; CPT2_HUMAN; CPTASE; CPTII; IIAE4; mitochondrial;

抗原和靶标

免疫原:

A synthesized peptide derived from human CPT2, corresponding to a region within the internal amino acids.

基因/基因ID:
CPT2(1376)
描述:
The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders.

研究领域

· Metabolism > Lipid metabolism > Fatty acid degradation.

· Metabolism > Global and overview maps > Fatty acid metabolism.

· Organismal Systems > Endocrine system > PPAR signaling pathway.

文献引用

1). Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization. Pharmacological research, 2021 (PubMed: 34343656) [IF=9.1]
2). SGMS1-AS1/MicroRNA-106a-5p/CPT2 Axis as a Novel Target for Regulating Lactate Metabolism in Colon Cancer. Technology in cancer research & treatment, 2023 (PubMed: 37926998) [IF=2.7]

Application: WB    Species: human    Sample:

Figure 7. Prediction of miRNAs and lncRNAs and construction of ceRNAs. (A) Expression of miRNA (hsa-miR-106a-5p) between tumor and normal samples and analysis of the expression correlation between miRNA (hsa-miR-106a-5p) and mRNA (CPT2). (B) Interaction network of miRNAs and reverse-predict lncRNAs as well as mRNA (CPT2). (C) Expression of lncRNA (SGMS1-AS1) between tumor and normal samples and analysis of the expression correlation between lncRNA (SGMS1-AS1) and miRNA (hsa-miR-106a-5p). (D) Expression correlation between lncRNA (SGMS1-AS1) and mRNA (CPT2). (E) Expression of mRNA (CPT2), lncRNA (SGMS1-AS1), and miRNA (hsa-miR-106a-5p) in cell lines and tissues. The number of clinical specimens is 24 cases, and detailed information is located in Supplemental Material Table S3. (F) Representative infiltration of CPT2-positive cells in colon tissue (400×) and data showing CPT2-positive cells in colon tissue, n  =  12. *P 
3). Mitochondrial dysfunction resulting from the down-regulation of bone morphogenetic protein 5 may cause microtia. Annals of Translational Medicine, 2021 (PubMed: 33842639)

Application: WB    Species: Human    Sample: 293T cells

Figure 6 Down-regulation of BMP5 attenuates mitochondrial fat oxidation and triglyceride synthesis. (A) The expression of CPT2 mRNA in 293T cells treated with BMP5-siRNA shows a larger decrease than that in the siNC group. (B) The expression of CPT2 mRNA in ADSCs treated with BMP5-siRNA decreased. (C) CPT2 protein expression in 293T cells treated with BMP5-siRNA shows a larger decrease than that in the siNC group. (D) The expression of DGAT2 mRNA in 293T cells treated with BMP5-siRNA decreased. (E) The expression of DGAT2 mRNA in ADSCs treated with BMP5-siRNA decreased. (F) DGAT2 protein expression in 293T cells treated with BMP5-siRNA decreased (G) Representative western blots of CPT2 and DGAT2 enzymes in 3 groups of 293T cells. *, P<0.05; **, P<0.01. BMP5, bone morphogenetic protein 5; ADSC, adipose-derived stem cells; NC, normal control; CPT2, carnitine O-palmitoyltransferase 2; DGAT2, diacylglycerol acyltransferase 2; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.

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