TGFBI Antibody - #DF7015

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产品: TGFBI 抗体
货号: DF7015
描述: Rabbit polyclonal antibody to TGFBI
应用: WB IHC IF/ICC
文献验证: IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Rabbit, Dog, Xenopus
蛋白号: Q15582
RRID: AB_2838971

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
TGFBI Antibody detects endogenous levels of total TGFBI.
RRID:
AB_2838971
引用格式: Affinity Biosciences Cat# DF7015, RRID:AB_2838971.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

RGD containing collagen associated protein; AI181842; AI747162; Beta ig; Beta ig h3; Beta ig-h3; BGH3_HUMAN; Big h3; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; Kerato epithelin; Kerato-epithelin; LCD1; MGC150270; RGD CAP; RGD-CAP; RGD-containing collagen-associated protein; TGFBI; TGFBI transforming growth factor, beta induced, 68kDa; Transforming growth factor beta induced protein ig h3; Transforming growth factor-beta-induced protein ig-h3;

抗原和靶标

免疫原:

A synthesized peptide derived from human TGFBI, corresponding to a region within N-terminal amino acids.

基因/基因ID:
TGFBI(7045)
描述:
TGFBI is a RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion.

文献引用

1). Integrated Analysis Identified TGFBI as a Biomarker of Disease Severity and Prognosis Correlated with Immune Infiltrates in Patients with Sepsis. Journal of inflammation research, 2024 (PubMed: 38645878) [IF=4.5]

Application: IHC    Species: human    Sample:

Figure 6 Exploring the potential functions of TGFBI. (A) Ten proteins with similar functions to TGFBI were identified using the String database. (B) A functional enrichment analysis of TGFBI and related proteins. (C) Single-cell data for peripheral blood mononuclear cell (PBMC) TGFBI derived from the Human Protein Atlas. (D) The expression of TGFBI in different subtypes of macrophages were analyzed in GSE159112 and validated by q-PCR on macrophages-derived from THP-1 cells. (E) Flow cytometry results showed that TGFBI improved M1 polarization of LPS-induced macrophages. (F) TGFBI was found to attenuate LPS-mediated phagocytosis in macrophages by Neutral Red Staining Solution. (G) ELISA results showed that TGFBI had different effects on LPS-mediated inflammatory factors (IL-6 and IL-10). *P

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