REG3G Antibody - #DF6869

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产品: REG3G 抗体
货号: DF6869
描述: Rabbit polyclonal antibody to REG3G
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
分子量: 19kDa;
蛋白号: O09049
RRID: AB_2838828

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
REG3G Antibody detects endogenous levels of total REG3G.
RRID:
AB_2838828
引用格式: Affinity Biosciences Cat# DF6869, RRID:AB_2838828.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

LPPM429; Pancreatitis-associated protein 1B; Pancreatitis-associated protein IB; PAP IB; PAP-1B; PAP1B; PAPIB; REG III; Reg III-gamma; REG-3-gamma; REG3G; REG3G_HUMAN; Regenerating islet derived 3 gamma; Regenerating islet-derived protein 3-gamma; Regenerating islet-derived protein III-gamma; UNQ429;

抗原和靶标

免疫原:

A synthesized peptide derived from Mouse REG3G, corresponding to a region within N-terminal amino acids.

描述:
The regeneration (REG) family consists of secretory proteins involved in liver, pancreatic, gastric and intestinal cell proliferation or differentiation. Members of the REG family are divided into four subclasses, designated types I, II, III and IV, all of which share a common gene structure containing five introns and six exons. Members of the Reg family have been implicated in the regulation of cell growth, tumorigenesis and the progression of cancer. Reg lll (regenerating islet-derived 3 gamma), also known as pancreatitis-associated protein 1B, PAP1B, or UNQ429, is a 175 amino acid secreted protein that is expressed almost exclusively in pancreas, with low levels of expression in testis. Reg lll functions as an antimicrobial protein involved in controlling bacterial proliferation and may be induced during acute pancreatitis. The gene encoding Reg lll maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome.

文献引用

1). Lentinan mitigates ulcerative colitis via the IL-22 pathway to repair the compromised mucosal barrier and enhance antimicrobial defense. International journal of biological macromolecules, 2025 (PubMed: 40054799) [IF=7.7]
2). RegⅢγ promotes the proliferation, and inhibits inflammation response of macrophages by Akt, STAT3 and NF-κB pathways. International immunopharmacology, 2024 (PubMed: 39490142) [IF=4.8]
3). Effects of Oltipraz on the Glycolipid Metabolism and the Nrf2/HO-1 Pathway in Type 2 Diabetic Mice. Drug design, development and therapy, 2024 (PubMed: 39654602) [IF=4.7]

Application: WB    Species: Mouse    Sample:

Figure 5 OLTI showed an anti-oxidation stress and anti-apoptosis function in T2DM. (A–G) the expression of Nrf2, HO-1, NQO1, Bax, Bcl-2, Caspase-3, and Reg3g in mRNA level. (H–O) the expression of Nrf2, HO-1, NQO1, Bax, Bcl-2, Caspase-3, and Reg3g in protein level. *P
4). Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency. PLoS One, 2022 (PubMed: 35108315) [IF=2.9]

Application: WB    Species: Mouse    Sample:

Fig 6. Decreased production of Reg3γ and β-defensins in IEC of OH mice. IEC were isolated from the small intestines of C, SH and OH mice, respectively. A: IEC expression of Reg3γ and β-defensins 1 and 3 in OH and the control mice were determined by qRT-PCR. B: Protein levels of Reg3γ and β-defensins 1 were determined by western blot. C: Relative density ratio of Reg3γ and β-defensins 1. IEC, intestinal epithelial cell; qRT-PCR, quantitative real-time polymerase chain reaction; C, normal diet (n = 8); SH, sham+HFD (n = 10); OH, OVX+HFD (n = 8); OVX, ovariectomy; HFD, high fat diet.

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