NUMBL Antibody - #DF6863

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产品: NUMBL 抗体
货号: DF6863
描述: Rabbit polyclonal antibody to NUMBL
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Dog
蛋白号: Q9Y6R0
RRID: AB_2838822

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
NUMBL Antibody detects endogenous levels of total NUMBL.
RRID:
AB_2838822
引用格式: Affinity Biosciences Cat# DF6863, RRID:AB_2838822.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CAG 3A; CAG3A; CTG 3a; CTG3a; NBL; NUMB Drosophilia Homolog Like; Numb homolog (Drosophila) like; Numb homolog like; Numb like protein; NUMB R; Numb-like protein; Numb-R; Numb-related gene; Numb-related protein; NUMBL; NUMBL_HUMAN; NUMBLIKE; NUMBR; TNRC 23; TNRC23; Trinucleotide repeat-containing gene 23;

抗原和靶标

免疫原:

A synthesized peptide derived from human NUMBL, corresponding to a region within C-terminal amino acids.

基因/基因ID:
NUMBL(9253)
描述:
Numb-like (Numbl or Nbl) binds Notch and is an intracellular modulator of Notch signaling pathway. Numbl contains a phosphotyrosine binding (PTB) domain that could bind the Y682 motif present in the cytoplasmic tail of APP. Deduced molecular weight of Numbl is 72 kDa.

研究领域

· Environmental Information Processing > Signal transduction > Notch signaling pathway.   (View pathway)

文献引用

1). miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence. Molecular Therapy-Nucleic Acids, 2020 (PubMed: 31790972) [IF=6.5]

Application: WB    Species: Human    Sample: Cartilage

Figure 5. Bioinformatics Analyses of the Potential Mechanisms by which miR-140 Regulates Chondrocyte Senescence (A) The number of predicted target genes of hsa-miR-140-5p in the miRDB, miRmap, PicTar, TargetScan, and DIANA microT-CDS databases. (B) Gene Ontology (GO) enrichment analysis for the predicted target genes of hsa-miR-140-5p, showing only the top 10 items in each category; the detailed results are provided in Figure S4. (C) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the predicted target genes of hsa-miR-140-5p (p < 0.05). (D and E) Experimental validation of the effect of miR-140 on the proteins encoded by the predicted target genes of hsa-miR-140-5p by western blotting, including JAG1 and NUMBL in the Notch pathway (D) and IGF1R and TLR4 in the PI3K-AKT pathway (E). *p < 0.05, **p < 0.01.

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