IGF2 Antibody - #DF6810

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产品: IGF2 抗体
货号: DF6810
描述: Rabbit polyclonal antibody to IGF2
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Horse, Rabbit, Dog
蛋白号: P01344
RRID: AB_2838771

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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实验方案
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
IGF2 Antibody detects endogenous levels of total IGF2.
RRID:
AB_2838771
引用格式: Affinity Biosciences Cat# DF6810, RRID:AB_2838771.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

C11orf43; IGF 2; IGF II; IGF-II; IGF2; IGF2_HUMAN; IGFII; INSIGF; insulin like growth factor 2 (somatomedin A); Insulin like Growth Factor 2; Insulin like growth factor II; Insulin like growth factor II precursor; Insulin like growth factor type 2; pp9974; Preptin; putative insulin like growth factor II associated protein; Somatomedin A; Somatomedin-A;

抗原和靶标

免疫原:

A synthesized peptide derived from human IGF2, corresponding to a region within the internal amino acids.

基因/基因ID:
IGF2(3481)
描述:
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilmstumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

研究领域

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

文献引用

1). IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced ulcerative colitis. European journal of pharmacology, 2023 (PubMed: 37863414) [IF=4.2]

Application: WB    Species: Mouse    Sample:

Fig. 1. IGF2 expression is down-regulated in DSS-induced colitis. A) The representative appearance changes and length of colons of DSS-induced colitis mice. n = 7. B,C) Body weight loss and disease activity index alteration in DSS-induced colitis. n = 9. D) Morphological images of DSS-induced colon injury evaluated by HE staining. Bar = 50 μm. Inflammatory cell infiltration (arrow-head), edema formation (asterisk sign) and crypt injury (pound sign). E,F) The mRNA level and protein level of IGF2 in colitis colons. n = 7. G,H) Contents of IGF2 in colons and plasma of colitis mice. n = 9. I,J) Contents of insulin in colons and plasma of colitis mice. n = 9. **P < 0.01, and ***P < 0.001 versus NC group.

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