EPHX1 Antibody - #DF6799

(3)  
产品: EPHX1 抗体
货号: DF6799
描述: Rabbit polyclonal antibody to EPHX1
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 53kDa; 53kD(Calculated).
蛋白号: P07099
RRID: AB_2838761

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(100%), Bovine(90%), Horse(100%), Sheep(100%), Rabbit(90%), Dog(90%), Chicken(100%), Xenopus(90%)
克隆:
Polyclonal
特异性:
EPHX1 Antibody detects endogenous levels of total EPHX1.
RRID:
AB_2838761
引用格式: Affinity Biosciences Cat# DF6799, RRID:AB_2838761.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EPHX 1; EPHX; Ephx1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; Epoxide hydrolase 1 microsomal (xenobiotic); Epoxide hydroxylase 1; Epoxide hydroxylase 1 microsomal (xenobiotic); HYEP_HUMAN; HYL1; MEH; Microsomal epoxide hydrolase;

抗原和靶标

免疫原:
Uniprot:

P07099(HYEP_HUMAN) >>Visit HPA database.

基因/基因ID:
EPHX1(2052)
表达:
P07099 HYEP_HUMAN:

Found in liver.

描述:
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
序列:
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Sheep
100
Zebrafish
100
Chicken
100
Bovine
90
Dog
90
Xenopus
90
Rabbit
90
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P07099 作为底物

Site PTM Type Enzyme
S47 Phosphorylation
K52 Ubiquitination
T55 Phosphorylation
S56 Phosphorylation
K91 Ubiquitination
K92 Ubiquitination
S95 Phosphorylation
K105 Ubiquitination
K117 Methylation
K119 Methylation
K131 Acetylation
K168 Ubiquitination
S173 Phosphorylation
K196 Ubiquitination
K197 Ubiquitination
T204 Phosphorylation
K210 Acetylation
Y283 Phosphorylation
K286 Ubiquitination
K288 Ubiquitination
Y291 Phosphorylation
S297 Phosphorylation
Y299 Phosphorylation
Y339 Phosphorylation
Y361 Phosphorylation
K386 Acetylation
K386 Ubiquitination
Y393 Phosphorylation
T408 Phosphorylation
S422 Phosphorylation
Y423 Phosphorylation
Y425 Phosphorylation
S450 Phosphorylation

研究背景

功能:

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids.

细胞定位:

Microsome membrane>Single-pass type III membrane protein. Endoplasmic reticulum membrane>Single-pass type III membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Found in liver.

蛋白家族:

Belongs to the peptidase S33 family.

研究领域

· Human Diseases > Cancers: Overview > Chemical carcinogenesis.

· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.

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