| 产品: | CAPZA2 抗体 |
| 货号: | DF6784 |
| 描述: | Rabbit polyclonal antibody to CAPZA2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 33kDa; 33kD(Calculated). |
| 蛋白号: | P47755 |
| RRID: | AB_2838746 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6784, RRID:AB_2838746.
展开/折叠
CAPPA2; Capping protein (actin filament) muscle Z line, alpha 2; CapZ alpha 2; CapZ alpha-2; CAPZ; CAPZA2; CAZA2_HUMAN; F actin capping protein alpha 2 subunit; F actin capping protein subunit alpha 2; F-actin-capping protein subunit alpha-2;
抗原和靶标
- P47755 CAZA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P47755 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K13 | Ubiquitination | Uniprot | |
| K19 | Acetylation | Uniprot | |
| K19 | Ubiquitination | Uniprot | |
| T63 | Phosphorylation | Uniprot | |
| K86 | Acetylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K97 | Acetylation | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| T142 | Phosphorylation | Uniprot | |
| Y144 | Phosphorylation | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| T180 | Phosphorylation | Uniprot | |
| Y198 | Phosphorylation | Uniprot | |
| K226 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K256 | Methylation | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| K268 | Sumoylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| K273 | Acetylation | Uniprot | |
| K273 | Sumoylation | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| Y277 | Phosphorylation | Uniprot | |
| K278 | Acetylation | Uniprot | |
| K278 | Sumoylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot |
研究背景
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP. Directly interacts with CRACD; this interaction decreases binding to actin.
Belongs to the F-actin-capping protein alpha subunit family.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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