AR Antibody - #DF6783

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产品: AR 抗体
货号: DF6783
描述: Rabbit polyclonal antibody to AR
应用: WB IHC
文献验证:
反应: Human, Mouse, Rat, Monkey
预测: Pig, Bovine, Sheep, Rabbit, Dog, Chicken
蛋白号: P10275
RRID: AB_2838745

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat, Monkey
克隆:
Polyclonal
特异性:
AR Antibody detects endogenous levels of total Androgen Receptor.
RRID:
AB_2838745
引用格式: Affinity Biosciences Cat# DF6783, RRID:AB_2838745.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AIS; ANDR_HUMAN; Androgen nuclear receptor variant 2; Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); Androgen receptor; androgen receptor splice variant 4b; AR; AR8; DHTR; Dihydro testosterone receptor; Dihydrotestosterone receptor (DHTR); Dihydrotestosterone receptor; HUMARA; HYSP1; KD; Kennedy disease (KD); NR3C4; Nuclear receptor subfamily 3 group C member 4 (NR3C4); Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; Spinal and bulbar muscular atrophy (SBMA); Spinal and bulbar muscular atrophy; Testicular Feminization (TFM); TFM;

抗原和靶标

免疫原:

A synthesized peptide derived from human AR, corresponding to a region within the internal amino acids.

基因/基因ID:
AR(367)
描述:
Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).

研究领域

· Cellular Processes > Cell growth and death > Oocyte meiosis.   (View pathway)

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Prostate cancer.   (View pathway)

文献引用

1). Bioinformatics-based analysis of the roles of sex hormone receptors in endometriosis development. International journal of medical sciences, 2023 (PubMed: 36860677) [IF=3.2]

Application: IF/ICC    Species: human    Sample: endometrial tissues

Figure 5. The expression of AR in human endometrial tissues. (A-D) Representative images of AR staining in postmenopausal endometrium (A), premenopausal endometrium (B), eutopic endometrium from endometriotic patients (C) and their matched ectopic lesion (D). (E) The corresponding histograms of positive AR staining level in different groups. (F) Representative images of AR staining in endometrial stromal cells. Scale bar 100 µm. AR, androgen receptor.
2). Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE/IGF-1/Akt, TGF-β/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice. Naunyn-Schmiedeberg's archives of pharmacology, 2024 (PubMed: 38700794) [IF=3.1]
3). Study on the changes of LHR, FSHR and AR with the development of testis cells in Hu sheep. Animal Reproduction Science, 2023 (PubMed: 37541020) [IF=2.2]

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