TRIM21 Antibody - #DF6717

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产品: TRIM21 抗体
货号: DF6717
描述: Rabbit polyclonal antibody to TRIM21
应用: WB IHC IF/ICC
文献验证: IHC
反应: Human, Mouse, Rat
蛋白号: P19474
RRID: AB_2838679

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
TRIM21 Antibody detects endogenous levels of total TRIM21.
RRID:
AB_2838679
引用格式: Affinity Biosciences Cat# DF6717, RRID:AB_2838679.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro protein; 52kD Ro/SSA autoantigen; Autoantigen Ro/SSA, 52-KD; E3 ubiquitin-protein ligase TRIM21; RING finger protein 81; RNF81; Ro 52; Ro(SS-A); Ro52; RO52_HUMAN; Sicca syndrome antigen A; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A1; Sjogren syndrome type A antigen; SS-A; SSA; SSA1: Sjogren syndrome antigen A1 (52kDa ribonucleoprotein autoantigen SS-A/Ro); TRIM21; Tripartite motif protein TRIM21; Tripartite motif-containing 21; Tripartite motif-containing protein 21;

抗原和靶标

免疫原:

A synthesized peptide derived from human TRIM21, corresponding to a region within C-terminal amino acids.

基因/基因ID:
TRIM21(6737)
描述:
TRIM21 has multiple N-terminal zinc finger motifs(has E3 ligase activity), a central leucine zipper, and a potential N-glycosylation site. TRIM3 is a E3 ubiquitin-protein ligase. It can form a ubiquitin ligase complex with E2 UBE2D2, which function not only for the uniquitination of USP4 and IKBKB but also for its self-ubiquitination. It has a role in the regulation of the cell cycle progression and could enhance the decapping activity of DCP2. It can exist in all mammalian cells as a ribonucleoprotein particle , which composed of a single polypeptide and 1 of 4 small RNA molecules.

研究领域

· Human Diseases > Immune diseases > Systemic lupus erythematosus.

文献引用

1). Anti-Ro/SSA Antibodies May Be Responsible for Cerebellar Degeneration in Sjogren's Syndrome. Journal of clinical medicine research, 2021 (PubMed: 33747326)

Application: IHC    Species: Mice    Sample: Purkinje cells

Figure 4 Photomicrographs of immunohistochemistry on murine cerebellar tissue sections. (a) Ro52/TRIM21 expression is shown using an anti-Ro52/TRIM21 antibody, but (b) is not present after staining with an anti-rabbit Ig (negative control). High Ro52/TRIM21 expression was observed in the cytoplasm of Purkinje cells. Arrowheads indicate representative Purkinje cells (magnification: × 40, counterstain: hematoxylin).

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