CNTF Antibody - #DF6689

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产品: CNTF 抗体
货号: DF6689
描述: Rabbit polyclonal antibody to CNTF
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Horse, Dog
蛋白号: P26441
RRID: AB_2838651

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CNTF Antibody detects endogenous levels of total CNTF.
RRID:
AB_2838651
引用格式: Affinity Biosciences Cat# DF6689, RRID:AB_2838651.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Ciliary neurotrophic factor; CNTF; CNTF_HUMAN; HCNTF;

抗原和靶标

免疫原:

A synthesized peptide derived from human CNTF, corresponding to a region within C-terminal amino acids.

基因/基因ID:
CNTF(1270)
描述:
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

文献引用

1). Ciliary neurotrophic factor promotes the development of homocysteine-induced vascular endothelial injury through inflammation mediated by the JAK2/STAT3 signaling pathway. Experimental cell research, 2024 (PubMed: 38848951) [IF=3.3]
2). Effect of Sonic hedgehog gene-modified bone marrow mesenchymal stem cells on graft-induced retinal gliosis and retinal ganglion cells survival in diabetic mice. International journal of ophthalmology, 2024 (PubMed: 38239953) [IF=1.9]

Application: WB    Species: Mouse    Sample:

Figure 4. MSC-Shh triggered secretion of neurotrophic factors and prevented RGCs loss. Western blot showed that the expression of BDNF and CNTF increased significantly after the administration of MSC-Shh, while the change of these factors was not significant after MSC-Gfp injection (A, B). Representative dissection of mice retina in each group were observed under confocal microscopy focusing on the ganglion cell layer of the retina (arrows; C). RGC quantification showed that the diabetic mice presented a significant reduction in the number of RGCs in the retina, and this reduction was significantly prevented after MSC-Shh and MSC-Gfp administration (D). Immunofluorescence staining of the whole-mount retina and RGC quantification showed that the surviving RGCs decreased significantly in the diabetic mice, and this reduction was significantly prevented after MSC-Shh administration (E, F). Quantitative data correspond to mean±SEM of four eyes per group and per analyzed time. aP

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