IL1R2 Antibody - #DF6682

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产品: IL1R2 抗体
货号: DF6682
描述: Rabbit polyclonal antibody to IL1R2
应用: WB IHC IF/ICC
文献验证: IHC, IF/ICC
反应: Human, Mouse
预测: Horse, Dog
蛋白号: P27930
RRID: AB_2838644

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
IL1R2 Antibody detects endogenous levels of total IL1R2.
RRID:
AB_2838644
引用格式: Affinity Biosciences Cat# DF6682, RRID:AB_2838644.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

IL1 Receptor II; Antigen CDw121b; CD121; CD121 antigen-like family member B; CD121b; CD121B Antigen; CDw121b; IL 1 type II receptor; IL-1R-2; IL-1R-beta; IL-1R2; IL-1RT-2; IL-1RT2; IL1R Beta; Il1r-2; IL1R2; IL1R2_HUMAN; IL1R2c; IL1RB; Interleukin 1 receptor type II variant 3; Interleukin 1 receptor, beta, type II; Interleukin 1 receptor, type II; Interleukin-1 receptor beta; Interleukin-1 receptor type 2; Interleukin-1 receptor type II; MGC137383; MGC47725; OTTHUMP00000207969; p68; Type II interleukin-1 receptor, beta;

抗原和靶标

免疫原:

A synthesized peptide derived from human IL1R2, corresponding to a region within C-terminal amino acids.

基因/基因ID:
IL1R2(7850)
描述:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Cancers: Specific types > Prostate cancer.   (View pathway)

· Organismal Systems > Immune system > Hematopoietic cell lineage.   (View pathway)

文献引用

1). Single-cell RNA sequencing reveals the impaired epidermal differentiation and pathological microenvironment in diabetic foot ulcer. Burns & trauma, 2025 (PubMed: 40040959) [IF=6.3]

Application: IF/ICC    Species: human    Sample:

Figure 2Subtypes of keratinocytes in NS, AW, and DFU tissues. (a) UMAP plot of keratinocytes. Keratinocytes are categorized by their respective types and annotated to the right. (b) Dot plot of marker genes highly expressed in each KC cluster. (c) Stacked bar plot of the proportions in each cluster. (d) Heatmap of the marker genes (red) in each basal cell cluster (BC-1, BC-2, BC-3, BC-4, and DAK). The selected marker genes and related biological functions for each cluster are displayed on the right. (e) mIHC analysis of IL1R2 (red), TXNIP (purple), KRT15 (green), and DAPI (blue) in each group of samples. Positive cells are labeled with arrows. The yellow scale bar represents 50 μm, and the magnification was 200X. The white scale bar represents 20 μm, and the magnification was 400X. (f) Quantitative analysis of IL1R2 + TXNIP+ cells. n = 3 for each group. The data represent the mean ± SD. **p 0.05. (g) mIHC analysis of SH3KBP1 (red), GRP (purple), KRT15 (green), and DAPI (blue) in each group of samples. Positive cells are labeled with arrows. The yellow scale bar represents 50 μm, and the magnification was 200X. The white scale bar represents 20 μm and the magnification was 400X. (h) Quantitative analysis of SH3KBP1 + GRP+ cells. n = 3 for each group. The data represent the mean ± SD. *p 0.05. Basal cells (BC), diabetes-associated keratinocytes (DAK), spinous cells (SC), granular cells (GC), hair follicle cells (HFC), and intermediate keratinocytes (inter-KC)
2). NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis. Frontiers in Immunology, 2021 (PubMed: 34630429) [IF=5.7]

Application: IHC    Species: Human    Sample: endometrial tissues

Figure 5 IL1R1 was over-expressed in ectopic endometrium. Representative photomicrographs of immunostaining with IL1R1 and IL1R2 in endometriotic lesions and eutopic endometrium from women with or without endometriosis. Scale bars = 100 μm. Immunostaining scores are represented as mean ± SEM. Statistical comparisons were carried out with Kruskal-Wallis test followed by Dunn’s multiple comparison test. *P < 0.05.

Application: IHC    Species: Human    Sample: endometrial tissues

Figure 5 IL1R1 was over-expressed in ectopic endometrium. Representative photomicrographs of immunostaining with IL1R1 and IL1R2 in endometriotic lesions and eutopic endometrium from women with or without endometriosis. Scale bars = 100 μm. Immunostaining scores are represented as mean ± SEM. Statistical comparisons were carried out with Kruskal-Wallis test followed by Dunn’s multiple comparison test. *P < 0.05.

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