SLC25A4 Antibody - #DF6674

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产品: SLC25A4 抗体
货号: DF6674
描述: Rabbit polyclonal antibody to SLC25A4
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
蛋白号: P12235
RRID: AB_2838636

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
SLC25A4 Antibody detects endogenous levels of total SLC25A4.
RRID:
AB_2838636
引用格式: Affinity Biosciences Cat# DF6674, RRID:AB_2838636.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AAC1; Adenine nucleotide translocator 1 (skeletal muscle); Adenine nucleotide translocator 1; ADP; ADP ATP carrier protein 1; ADP ATP carrier protein heart/skeletal muscle isoform T1; ADP/ATP translocase 1; ADT1_HUMAN; ANT 1; ANT; ANT1; ATP carrier protein 1; ATP carrier protein; heart/skeletal muscle isoform T1; PEO2; PEO3; SLC25A4; Solute carrier family 25 member 4; T1;

抗原和靶标

免疫原:

A synthesized peptide derived from human SLC25A4, corresponding to a region within the internal amino acids.

基因/基因ID:
SLC25A4(291)
描述:
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy.

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Human Diseases > Neurodegenerative diseases > Parkinson's disease.

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

文献引用

1). Oligodendrocyte-astrocyte crosstalk in Parkinson's disease mediates neuronal ferroptosis via the FGF signaling pathway. NPJ Parkinson's disease, 2025 (PubMed: 40410211) [IF=8.7]

Application: WB    Species: Mouse    Sample:

Fig. 7: Oxidative phosphorylation and ferroptosis processes are activated in oligodendrocytes and astrocytes. A The results of the Western Blot show that the protein expression levels of Slc25a4, Ndufa4, and Atp6v0c, which are related to mitochondrial oxidative phosphorylation, are significantly increased in astrocytes and oligodendrocytes under PD conditions. Additionally, in PD astrocytes, there is a significant decrease in the expression of the Mt1 protein. B The results of the ELISA kit show that the Ca2+ content in astrocytes of PD mice is significantly increased. At the same time, the iron ion content in the SN of mice is significantly elevated, while the GSH content, total SOD activity, and MDA content are significantly decreased, indicating the presence of high levels of ROS and the activation of ferroptosis processes in the SN of PD mice.

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